Advances in the mechanism of alveolar macrophage-induced immune response to inflammation injury of lung tissue

doi:10.16352/j.issn.1001-6325.2023.10.1585

Abstract

Abstract: As specialized antigen-presenting cells, alveolar macrophages play an important role in host immune defense and adaptive immune response. After local infection caused by pathogens which colonize lung tissue, alveolar macrophages can recognize and engulf pathogens through pattern recognition receptors on their surface. In severe cases, the marophages may be further activated to present the ingested antigenic material to adaptive immune cells, and can be converted into a pro-inflammatory or anti-inflammatory phenotype depending on changes in the tissue microenvironment.By releasing relevant signaling factors, immune responses could regulate lung inflammation injury and tissue repair.

Key words: bacterial pneumonia, alveolar macrophages, inflammatory injury, immune response

CLC Number:

R392.9

ZHANG Chen, PU Xiang, SU Jin, TANG Yilian, ZENG Xianfa. Advances in the mechanism of alveolar macrophage-induced immune response to inflammation injury of lung tissue[J]. Basic & Clinical Medicine, 2023, 43(10): 1585-1589.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2023.10.1585

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2023/V43/I10/1585

References

[1]孙国先,刘微丽,郑庆斌,等.PCT与SDI比值对重症细菌性肺炎患者短期预后的预测价值[J].中国感染控制杂志,2022,21:885-890.
[2]邱少聪,未先洁,徐江荣.重症肺炎患者病原学特点及血清ChE、RAGE水平与病情进展的关系[J].中国病原生物学杂志,2021,16:1465-1469+1473.
[3]Bissonnette EY, Lauzon-Joset JF, Debley JS, et al. Cross-talk between alveolar macrophages and lung epith-elial cells is essential to maintain lung homeostasis[J].Front Immunol, 2020,11: 583042. doi: 10.3389/fimmu.2020.583042.
[4]Guillon A, Arafa EI, Barker KA, et al. Pneumonia recovery reprograms the alveolar macrophage pool[J].JCI Insight,2020,5:e133042.doi: 10.1172/jci.insight.133042.
[5]Soni S, O′Dea KP, Abe E, et al. Microvesicle-mediated communication within the alveolar space: mechanisms of uptake by epithelial cells and alveolar macrophages[J].Front Immunol, 2022,13:853769. doi: 10.3389/fimmu.2022.853769.
[6]Woo YD, Jeong D, Chung DH. Development and functions of alveolar macrophages[J].Mol Cells,2021,44:292-300.
[7]Martin FP, Jacqueline C, Poschmann J, et al. Alveolar macrophages: adaptation to their anatomic niche during and after inflammation[J]. Cells,2021,10:2720.doi: 10.3390/cells10102720.
[8]Zhang Y, Yuan D, Li Y, et al. Paraquat promotes acute lung injury in rats by regulating alveolar macrophage polarization through glycolysis[J]. Ecotoxicol Environ Saf,2021,223:112571. doi: 10.1016/j.ecoenv.2021.112571.
[9]Gschwend J, Sherman SPM, Ridder F, et al. Alveolar macrophages rely on GM-CSF from alveolar epithelial type 2 cells before and after birth[J]. J Exp Med, 2021,218: e20210745.doi: 10.1084/jem.20210745.
[10]Nawroth JC, van der Does AM, Ryan Firth A, et al. Multiscale mechanics of mucociliary clearance in the lung[J].Philos Trans R Soc Lond B Biol Sci,2020,375:20190160.doi: 10.1098/rstb.2019.0160.
[11]王卓,闫曙光,惠毅,等.麻黄-大黄药对抑制肺泡巨噬细胞M1极化防治急性肺损伤的作用机制[J].中国药理学通报,2022,38:1421-1429.
[12]Gao DK, Salomonis N, Henderlight M, et al. IFN-γ is essential for alveolar macrophage- driven pulmonary inflammation in macrophage activation syndrome[J].JCI Insight, 2021, 6: e147593. doi: 10.1172/jci.insight.147593.
[13]Liu Q, Wang HY. Interferon-γ-mediated gene expression in porcine alveolar macrophage; An in vitro model[J].Pol J Vet Sci, 2021,24: 135-143.
[14]高小玲,刘雪宁,吴耀松,等.基于PPARγ研究补肺益肾方对肺泡巨噬细胞胞葬功能障碍的改善机制[J].中药药理与临床,2021,37:169-173.
[15]Nguyen TKT, d′Aigle J, Chinea L, et al. Mycobacterial trehalose 6,6'-dimycolate-induced M1-type inflammation[J].Am J Pathol, 2020,190:286-294.
[16]Jiang W, Wang JM, Luo JH, et al. Airway epithelial integrin β4-deficiency exacerbates lipopolysaccharide-induced acute lung injury[J].J Cell Physiol, 2021, 236: 7711-7724.
[17]薛高峰,王琳源,关宁,等.全反式维甲酸对M1型巨噬细胞极化的影响[J].中国医科大学学报,2022,51:17-22.
[18]寇育乐,王文霸,闫曙光,等.基于NF-κB/NLRP3信号通路和肺泡巨噬细胞活化研究肺肠合治法抑制炎症反应治疗急性肺损伤的作用机制[J].中国中药杂志, 2022,47:151-158.
[19]Liu F, Peng W, Chen J, et al. Exosomes eerived from alveolar epithelial cells promote alveolar macrophage activation mediated by miR-92a-3p in sepsis-induced acute lung injury[J].Front Cell Infect Microbiol, 2021,11:646546.doi: 10.3389/fcimb.2021.646546.
[20]赵婧,焦卓亚,王娟,等.TLR4/NF-κB信号通路在SiO2所致矽肺模型肺泡巨噬细胞脂质代谢调控中的作用[J].中国临床解剖学杂志,2022,40:309-314.
[21]李亮,李建忠,刘士源,等.中性粒细胞胞外诱捕网在肺炎克雷伯菌肺部感染小鼠模型巨噬细胞激活过程中的调控作用[J].中华医院感染学杂志,2023,33:1285-1288.
[22]徐苏晴,常明,宓兰兰,等.中性粒细胞胞外诱捕网在新生大鼠急性肺损伤中的作用[J].中国病理生理杂志,2020,36:913-917+923.
[23]Shi LN, Zhou Y, Wu C, et al. Light of pulmonary NKT cells annihilates tissue protective alveolar macrophages in augmenting severe influenza pneumonia[J].Sci Bull,2021,66:2124-2134.
[24]Nueangphuet P, Suwanruengsri M, Fuke N, et al. Neutrophil and M2-polarized macrophage infiltration, expression of IL-8 and apoptosis in mycoplasma hyopneumoniae pneumonia in swine[J].J Comp Pathol, 2021,189:31-44.
[25]Gu S, Dai H, Zhao X, et al. AKT3 deficiency in M2 macrophages impairs cutaneous wound healing by disrupt-ing tissue remodeling[J].Aging (Albany NY), 2020,12: 6928-6946.
[26]Zhao X, Yu Z, Lv Z, et al. Activation of alpha-7 nicotinic acetylcholine receptors (α7nAchR) promotes the protective autophagy in LPS-induced acute lung injury (ALI) in vitro and in vivo[J]. Inflammation,2019,42:2236-2245.
[27]Xia L, Zhang C, Lv N, et al. AdMSC-derived exosomes alleviate acute lung injury via transferring mitochondrial component to improve homeostasis of alveolar macrophages[J]. Theranostics. 2022,12:2928-2947.
[28]胡琪,李瑞语,施昌盛,等.ATP酶抑制因子1对脂多糖诱导的小鼠肺泡巨噬细胞炎症反应及线粒体自噬的影响[J].中国病理生理杂志,2023,39:846-854.
[29]Chen H, Lin H, Dong B, et al. Hydrogen alleviates cell damage and acute lung injury in sepsis via PINK1/Parkin-mediated mitophagy[J]. Inflamm Res, 2021,70:915-930.
[30]罗传皊,孙利平,戚成栋.Lnc-MALAT1减轻miR-217抑制LPS诱导的大鼠肺泡巨噬细胞炎性反应[J].基础医学与临床,2021,41:404-408.