Research progress on the role of canonical transient receptor potential channels in skeletal muscle diseases

doi:10.16352/j.issn.1001-6325.2023.08.1309

Abstract

Abstract: Canonical transient receptor potential(TRPC) is a kind of non-selective cation channel located in the cell membrane, which plays an important role in electrophysiological activity of cells. Under pathological conditions, TRPC channels are more selective for Ca²⁺, which will break the Ca²⁺ homeostasis in skeletal muscle cells and lead to calcium overload and subsequent occurrence of a variety of skeletal muscle diseases. To study the role and mechanism of TRPC channels in skeletal muscle diseases is helpful to provide new ideas for disease treatment.

Key words: canonical transient receptor potential(TRPC) channel, skeletal muscle, skeletal muscle diseases, calcium ions

CLC Number:

XIE Dongge, LI Junhao, HAN Han, LI Shoutian. Research progress on the role of canonical transient receptor potential channels in skeletal muscle diseases[J]. Basic & Clinical Medicine, 2023, 43(8): 1309-1312.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2023.08.1309

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2023/V43/I8/1309

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