Basic & Clinical Medicine ›› 2023, Vol. 43 ›› Issue (7): 1152-1156.doi: 10.16352/j.issn.1001-6325.2023.07.1152

• Mini Reviews • Previous Articles     Next Articles

Progress of specialized pro-resolving mediators in diabetic kidney disease

LIU Chong1, LIU Yingying2, GUO Zhaoan2,*   

  1. 1. School of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan 250000;
    2. The First Department of Nephrology, Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250014, China
  • Received:2022-04-14 Revised:2022-10-13 Published:2023-07-05

Abstract: Specialized pro-resolving mediators (SPMs) can promote the regression of chronic inflammatory response in diabetic kidney disease (DKD), inhibit renal fibrosis and protect renal function by inhibiting renal intrinsic cell inflammatory response, antioxidant stress injury and regulate macrophage transformation. With the in-depth study of SPMs, it is expected to become a new target for the treatment of chronic inflammatory diseases such as DKD.

Key words: specialized pro-resolving mediators, inflammatory regulation, pro-inflammatory resolution, diabetic kidney disease

CLC Number: