Research progress on the role of endometrial glucose transporters in embryo implantation

doi:10.16352/j.issn.1001-6325.2023.06.1002

Abstract

Abstract: Glucose transporters are important carriers that mediate glucose transport across cell membranes, including facilitated diffusion glucose transporters (GLUTs), sodium glucose co transporters (SGLTs), and a class of glucose transporters SWEETs that have not been extensively studied. Glucose uptake and utilization of endometrial epithelial cells during implantation can ensure normal implant-related functional activities. The purpose of this paper is to elucidate the role of glucose transporter in embryo implantation in order to further reveal the mechanism of embryo implantation and provide new ideas for the diagnosis and treatment of female infertility and early abortion caused by implantation failure.

Key words: endometrium, glucose transporter, embryo implantation

CLC Number:

R339.22

ZHANG Lixue, LI Changxing. Research progress on the role of endometrial glucose transporters in embryo implantation[J]. Basic & Clinical Medicine, 2023, 43(6): 1003-1007.

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URL: http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/10.16352/j.issn.1001-6325.2023.06.1002

http://journal11.magtechjournal.com/Jwk_jcyxylc/EN/Y2023/V43/I6/1003

References 22

[1]	Deng D, Yan N. GLUT, SGLT, and SWEET: structural and mechanistic investigations of the glucose transporters[J]. Protein Sci, 2016, 25: 546-558.
[2]	Wang H, Dey S. Roadmap to embryo implantation: clues from mouse models[J]. Nat Rev Genet, 2006, 7: 185-199.
[3]	Zhang H, Qi J, Wang Y, et al. Progesterone regulates glucose metabolism through glucose transporter 1 to promote endometrial receptivity[J]. Front Physiol, 2020, 11:543148. doi:10.3389/fphys.2020.543148.
[4]	Nie L, Zhao Y, Zhao D, et al. Progesterone-induced miR-152 interferes with embryonic implantation by downregulating GLUT3 in endometrial epithelium[J]. Am J Physiol Endocrinol Metab, 2019, 316: E557-E567.
[5]	Zhang L, Song J, Ma Y, et al. Expression of SGLT1 in the mouse endometrial epithelium and its role in early embryonic development and implantation[J]. Reprod Sci, 2021,28:3094-3108.
[6]	Long Y, Wang Y, Yuan D, et al. GLUT4 in mouse endometrial epithelium: roles in embryonic development and implantation[J]. Front Physiol, 2021, 12:674924. doi:10.3389/fphys.2021.674924.
[7]	Ma Y, Cui Z, Zhao D, et al. The effects of altered endometrial glucose homeostasis on embryo implantation in type 2 diabetic mice[J]. Reprod Sci, 2021,28:703-704.
[8]	Salker M, Singh Y, Zeng N, et al. Loss of endometrial sodium glucose cotransporter SGLT1 is detrimental to embryo survival and fetal growth in pregnancy[J]. Sci Rep, 2017, 7: 12612. doi:10.1038/s41598-017-11674-3.
[9]	Zhang X, Zhao D, Ma Y, et al. Impact of disturbed glucose homeostasis regulated by AMPK in endometrium on embryo implantation in diabetes mice[J]. Reprod Sci, 2020, 27: 1752-1757.
[10]	Girish CJ, Kotur NS, Manjunath ML. A correlative study of endometrial glycogen content and other contributory factors on female infertility[J]. International Journal of Biomedical & Advance Research, 2012, 3. doi: 10.7439/ijbar.v3i1.225.
[11]	Arhin S, Zhao J, Ji X, et al. Multiple facilitated glucose transporters SLC2As are required for normal mouse preimplantation embryo development[J]. Am J Transl Res, 2019, 11: 3412-3425.
[12]	Doblado M, Moley K. Glucose metabolism in pregnancy and embryogenesis[J]. Curr Opin Endocrinol Diabetes Obes, 2007, 14: 488-493.
[13]	Bolouki A, Zal F, Alaee S. Ameliorative effects of quercetin on the preimplantation embryos development in diabetic pregnant mice[J]. J Obstet Gynaecol Res, 2020, 46: 736-744.
[14]	KšiйanovÁ M,KovaRÍkovÁ V, ŠefCÍkovÁ Z, et al. Different response of embryos originating from control and obese mice to insulin in vitro[J]. J Reprod Dev, 2021, 67: 25-34.
[15]	Riley J, Carayannopoulos M, Wyman A, et al. Phosphatidylinositol 3-kinase activity is critical for glucose metabolism and embryo survival in murine blastocysts[J]. J Biol Chem, 2006, 281: 6010-6019.
[16]	Burkus J, Navarrete Santos A, Schindler M, et al. Adiponectin stimulates glucose uptake in mouse blastocysts and embryonic carcinoma cells[J]. Reproduction, 2020, 159: 227-239.
[17]	Chi M, Schlein A, Moley K. High insulin-like growth factor 1 (IGF-1) and insulin concentrations trigger apoptosis in the mouse blastocyst via down-regulation of the IGF-1 receptor[J]. Endocrinology, 2000, 141: 4784-4792.
[18]	Eng G, Sheridan R, Wyman A, et al. AMP kinase activation increases glucose uptake, decreases apoptosis, and improves pregnancy outcome in embryos exposed to high IGF-I concentrations[J]. Diabetes, 2007, 56: 2228-2234.
[19]	Tso L, Costello M, Albuquerque L, et al. Metformin treatment before and during IVF or ICSI in women with polycystic ovary syndrome[J]. Cochrane Database Syst Rev, 2020, 12: CD006105. doi:10.1002/14651858.CD006105.pub4.
[20]	Chi F, Sharppley M, Nagaraj R, et al. Glycolysis-Independent glucose metabolism distinguishes TE from ICM fate during mammalian embryogenesis[J]. Dev Cell, 2020, 53: 9-26.e4.
[21]	孙晓方,陈适,卢琳,等.糖原累积病Ⅰb型1例的临床和分子遗传分析[J].基础医学与临床,2011,31:529-533.
[22]	Belli M, Rinaudo P, Palmerini M, et al. Pre-implantation mouse embryos cultured in vitro under different oxygen concentrations show altered ultrastructures[J]. Int J Environ Res Public Health, 2020, 17. doi:10.3390/ijerph17103384.