Basic & Clinical Medicine ›› 2022, Vol. 42 ›› Issue (12): 1850-1854.doi: 10.16352/j.issn.1001-6325.2022.12.1850

• Original Articles • Previous Articles     Next Articles

Intrahippocampal injection of irisin ameliorates depression-like behaviors in mice

LI Jing1, HUANG Bing-xuan2, XU Qi1*   

  1. 1. Department of Biochemistry and Molecular Biology, Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences CAMS, School of Basic Medicine PUMC, Beijing 100005;
    2. Beijing No. 166 High School, Beijing 100006, China
  • Received:2022-04-02 Revised:2022-06-28 Online:2022-12-05 Published:2022-11-23
  • Contact: *

Abstract: Objective To investigate the effects of irisin on the depression-like behaviors in depression mice. Methods C57BL/6 mice were randomly divided into model and healthy groups. Mice in the model group were trained by open-space forced swim (OSFS) model and then were sub-divided into “model-control” and “model-irisin”. Healthy wild mice were bred normally and sub-divided into “healthy-control” and “healthy-irisin”groups. All mice in test group and in control groups were injected with 77 pmol irisin or the solvent (PBS) into both hippocampi by brain stereotactic injection, respectively. Depression-like behaviors were examined by forced swim test (FST) and tail suspension test (TST). Results Compared with the healthy ones, the model mice showed a markedly prolonged immobility time in FST(P<0.01) and TST(P<0.05), which indicated that the successfully established model can simulate the despair-like behaviors of patients with depression. Compared with the “model-control”, irisin can remarkably reduce the immobility time of “model-irisin” mice in FST(P<0.001) and TST(P<0.05). Conclusions Irisin can significantly improve the depression-like behaviors of OSFS depression mice.

Key words: irisin, depression, physical exercise, antidepressant

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