跨膜蛋白质在恶性肿瘤中作用的研究进展

doi:10.16352/j.issn.1001-6325.2024.03.0398

基础医学与临床 ›› 2024, Vol. 44 ›› Issue (3): 398-402.doi: 10.16352/j.issn.1001-6325.2024.03.0398

跨膜蛋白质在恶性肿瘤中作用的研究进展

王子豪, 夏小超, 李舜^*

川北医学院附属医院,四川南充 637000

收稿日期:2023-05-16 修回日期:2023-11-29 出版日期:2024-03-05 发布日期:2024-02-22
通讯作者: ^*:morelee@163.com
基金资助:
南充市市校科技战略合作专项(19SXH20321);川北医学院附属医院项目(2019ZD001);川北医学院校级科研发展计划项目(CBY23-ZDA01)

Research progress on the role of transmembrane proteins in malignant tumors

WANG Zihao, XIA Xiaochao, LI Shun^*

The Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

Received:2023-05-16 Revised:2023-11-29 Online:2024-03-05 Published:2024-02-22
Contact: ^*:morelee@163.com

摘要/Abstract

摘要： 跨膜蛋白质(TMEMs)是一种横跨脂质生物膜的蛋白质家族,它作为生物膜上的通道蛋白质发挥着重要的生理作用。TMEMs在恶性肿瘤中表达上调促进恶性肿瘤进展,例如TMEM16A、TMEM206,也有表达下调促进恶性肿瘤发展的TMEM100,以及在不同恶性肿瘤的表达相反的TMEM98,可作为肿瘤的治疗靶点和预后标志物。此外,TMEMs通过不同上下游调控因子通过Wnt、AKT信号通路的发挥作用,以及在某些恶性肿瘤细胞中对顺铂相关化学耐药性有进一步的研究。

关键词: 跨膜蛋白质, 恶性肿瘤, 信号通路, 化学耐药性

Abstract: Transmembrane proteins (TMEMs) are a class of family proteins that span lipid bilayers, serving as crucial channel proteins on biological membranes, playing essential physiological roles. TMEMs′ over-expression in malignant tumors, such as TMEM16A and TMEM206, has been linked to the promotion of malignancy. Conversely, down-regulation of TMEM100 expression has been associated with tumor progression. TMEM98, whose expression varies across different malignancies.TMEMs has shown promise as both a therapeutic target and a prognostic marker in cancer.Additionally, TMEMs play a vital role in various malignancies by modulating the Wnt and AKT signaling pathways through interaction with different upstream and downstream regulatory factors. Furthermore, research has provided additional insights into their role in cisplatin-related chemoresistance in specific malignant tumor cell populations.

Key words: transmembrane protein, cancer, signaling pathway, chemoresistance

中图分类号:

王子豪, 夏小超, 李舜. 跨膜蛋白质在恶性肿瘤中作用的研究进展[J]. 基础医学与临床, 2024, 44(3): 398-402.

WANG Zihao, XIA Xiaochao, LI Shun. Research progress on the role of transmembrane proteins in malignant tumors[J]. Basic & Clinical Medicine, 2024, 44(3): 398-402.

参考文献 27

[1]	Bae Y, Lee SK, Chae YC, et al. Accessibility-dependent topology studies of membrane proteins using a SpyTag/SpyCatcher protein-ligation system[J]. Int J Biol Macromol, 2021, 175: 171-178.
[2]	Zhang N, Pan H, Liang X, et al. The roles of transmembrane family proteins in the regulation of store-operated Ca2+ entry[J]. Cell Mol Life Sci, 2022, 79: 118.doi:10.1007/s00018-021-04034-y.
[3]	Li C, Ou R, Chen Y, et al. Mutation analysis of TMEM family members for early-onset Parkinson′s disease in Chinese population[J]. Neurobiol Aging, 2021, 101: 299.e1-299.e6.doi:10.1016/j.neurobiolaging.2020.11.005.
[4]	Ji W, Shi D, Shi S, et al. TMEM16A protein: calcium-binding site and its activation mechanism[J]. PPL, 2021, 28: 1338-1348.
[5]	Ma K, Liu S, Liang H, et al. Ca2+-activated Cl-channel TMEM16A inhibition by cholesterol promotes angiogenesis in endothelial cells[J]. J Adv Res, 2021, 29: 23-32.
[6]	Luo S, Wang H, Bai L, et al. Activation of TMEM16A Ca2+-activated Cl-channels by ROCK1/moesin promotes breast cancer metastasis[J]. J Adv Res, 2021, 33: 253-264.
[7]	Yang J, Chen J, Del Carmen Vitery M, et al. PAC, an evolutionarily conserved membrane protein, is a proton-activated chloride channel[J]. Science, 2019, 364: 395-399.
[8]	Zha X, Xiong Z, Simon R, et al. pH and proton-sensitive receptors in brain ischemia[J]. J Cereb Blood Flow Metab, 2022,42:1349-1363.
[9]	Mihaljević L, Ruan Z, Osei-Owusu J, et al. Inhibition of the proton-activated chloride channel PAC by PIP2[J]. eLife, 2023, 12: e83935. doi: 10.7554/eLife.83935.
[10]	Peng F, Li H, Li J, et al.Downregulation of the proton-activated Cl- channel TMEM206 inhibits malignant properties of human osteosarcoma cells[J]. Oxid Med Cell Longev, 2021, 2021: 1-16.
[11]	Li M, Zhu H, Hu X, et al. TMEM98, a novel secretory protein, promotes endothelial cell adhesion as well as vascular smooth muscle cell proliferation and migration[J]. Can J Physiol Pharmacol, 2021, 99: 536-548.
[12]	Li J, Chen W, Luo L, et al. The microRNA miR-29c-5p inhibits cell proliferation and migration by targeting TMEM98 in head and neck carcinoma[J]. Aging, 2021, 13: 769-781.
[13]	Ao X, Li X, Chen Y, et al. TMEM98 mRNA promotes proliferation and invasion of gastric cells by directly interacting with NF90 protein[J]. Cell Biol Int, 2020, 44: 1820-1830.
[14]	Wu SG, Xu JY, Lei J, et al. Tumor-suppressor gene transmembrane protein 98 promotes proliferation and inhibits apoptosis in ovarian cancer[J]. Front Biosci(Landmark Ed), 2022, 27: 210. doi: 10.31083/j.fbl2707210.
[15]	He Q, Dong Y, Zhu Y, et al. TMEM100 induces cell death in non-small cell lung cancer via the activation of autophagy and apoptosis[J]. Oncol Rep, 2021, 45: 63. doi: 10.3892/or.2021.8014.
[16]	Li H, Cheng C, You W, et al. TMEM100 modulates TGF-β signaling pathway to inhibit colorectal cancer progression[J]. Gastroent Res Pract, 2021, 2021: 1-10.
[17]	Ye Z, Xia Y, Li L, et al. Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway[J]. Transl Oncol, 2023, 27: 101578. doi: 10.1016/j.tranon.2022.101578.
[18]	Liu J, Xiao Q, Xiao J, et al. Wnt/β-catenin signalling: function, biological mechanisms, and therapeutic opportunities[J]. Sig Transduct Target Ther, 2022, 7: 3. doi: 10.1038/s41392-021-00762-6.
[19]	Xu J, Su Z, Ding Q, et al. Inhibition of proliferation by knockdown of transmembrane (TMEM) 168 in glioblas-toma cells via suppression of Wnt/β-Catenin pathway[J]. oncol res, 2019, 27: 819-826.
[20]	Jiang XY, Wang L, Liu ZY, et al. TMEM48 promotes cell proliferation and invasion in cervical cancer via activation of the Wnt/β-catenin pathway[J]. J Recept Sig Transd, 2021, 41: 371-377.
[21]	Zhao X, Li G, Chong T, et al. TMEM88 exhibits an antiproliferative and anti-invasive effect in bladder cancer by downregulating Wnt/β-catenin signaling[J]. J Biochem Molecular Tox, 2021, 35: e22835. doi: 10.1002/jbt.22835.
[22]	Chen J, Wang D, Chen H, et al. TMEM196 inhibits lung cancer metastasis by regulating the Wnt/β-catenin signaling pathway[J]. J Cancer Res Clin Oncol, 2023, 149: 653-667.
[23]	Revathidevi S, Munirajan AK. Akt in cancer: mediator and more[J]. Semin Cancer Biol, 2019, 59: 80-91.
[24]	Zhan B, Zhang Z, Piao C, et al. The sigma-2 receptor/TMEM97 agonist PB28 suppresses cell proliferation and invasion by regulating the PI3K-AKT-mTOR signalling pathway in renal cancer[J]. J Cellular Molecular Medi, 2021, 25: 11244-11256.
[25]	Zhang X, He Y, Jiang Y, et al. TMEM229A suppresses non-small cell lung cancer progression via inactivating the ERK pathway[J]. Oncol Rep, 2021, 46: 176. doi: 10.3892/or.2021.8127.
[26]	Tchounwou PB, Dasari S, Noubissi FK, et al. Advances in our understanding of the molecular mechanisms of action of cisplatin in cancer therapy[J]. JEP, 2021, 13: 303-328.
[27]	Shen D, Ma J, Okabe M, et al. Elevated expression of TMEM205, a hypothetical membrane protein, is associa-ted with cisplatin resistance[J]. J Cell Physiol, 2010, 225: 822-828.

跨膜蛋白质在恶性肿瘤中作用的研究进展

Research progress on the role of transmembrane proteins in malignant tumors

PDF

可视化

摘要/Abstract

引用本文

使用本文

参考文献 27

相关文章 15

编辑推荐

Metrics

本文评价

[1]	肖艳红, 姜明东, 林叶远, 冉灿, 梁博. 灯盏花乙素抑制人前列腺癌细胞系PC-3的增殖和迁移[J]. 基础医学与临床, 2024, 44(9): 1229-1235.
[2]	蒋苏, 吕新翔, 崔艳红, 吕李婷, 李东霞. 吴茱萸碱对特应性皮炎模型大鼠的治疗作用[J]. 基础医学与临床, 2024, 44(9): 1256-1262.
[3]	金庆, 丁佑铭. FOXC1在消化系统癌发生发展中作用的研究进展[J]. 基础医学与临床, 2024, 44(7): 1049-1053.
[4]	高寅洁, 童安莉. 醛固酮产生腺瘤中细胞死亡和增殖机制[J]. 基础医学与临床, 2024, 44(6): 758-762.
[5]	徐璐, 张冬雨, 王瑞锋. 茯苓酸调节PI3K/AKT/NF-κB信号通路对大鼠幽门螺旋杆菌相关性胃炎的治疗作用[J]. 基础医学与临床, 2024, 44(4): 489-495.
[6]	吴玉红, 喻才元, 叶石才. NMES1基因在恶性肿瘤中作用的研究进展[J]. 基础医学与临床, 2024, 44(3): 403-407.
[7]	韩惠晶, 吴红, 葛银, 乔娟. 右美托咪定减轻呼吸机相关性肺损伤模型大鼠肺组织损伤[J]. 基础医学与临床, 2024, 44(3): 339-345.
[8]	陈卫卫, 廖煌, 史振鸿, 罗颖. FHL2通过NF-κB信号通路调节THP-1巨噬细胞泡沫化[J]. 基础医学与临床, 2024, 44(2): 204-209.
[9]	李炜康, 李东宝, 任嘉裕, 孙小童, 段开鹏, 周进. Ghrelin在胃癌中的作用[J]. 基础医学与临床, 2024, 44(10): 1460-1464.
[10]	邓娟, 王秀芳, 孙瑞青. 汉黄芩素促进自身免疫性肝炎模型大鼠Th17/Treg细胞平衡[J]. 基础医学与临床, 2024, 44(1): 77-83.
[11]	潘闪, 林铿强, 陈树兴. 培美曲塞抑制人肺腺癌细胞系A549增殖[J]. 基础医学与临床, 2023, 43(9): 1359-1363.
[12]	王琼, 董倩兰, 朱燕亭, 金刚, 张琳萍. 桔梗皂苷D减轻大鼠肾缺血/再灌注损伤[J]. 基础医学与临床, 2023, 43(8): 1222-1228.
[13]	邹宇祥, 唐慧. TLR2在消化道肿瘤发生发展中作用的研究进展[J]. 基础医学与临床, 2023, 43(8): 1304-1308.
[14]	王帆, 邓勇志. 微小RNAs在心肌肥厚中作用和分子机制的研究进展[J]. 基础医学与临床, 2023, 43(7): 1167-1170.
[15]	秦玉春, 邝向东, 蔡林再, 谢景臣, 陈山. 双氢青蒿素减轻慢性阻塞性肺疾病(COPD)模型大鼠肺损伤[J]. 基础医学与临床, 2023, 43(3): 427-432.