NR4A1在糖尿病肾病发病中作用的研究进展

doi:10.16352/j.issn.1001-6325.2023.10.1608

基础医学与临床 ›› 2023, Vol. 43 ›› Issue (10): 1608-1611.doi: 10.16352/j.issn.1001-6325.2023.10.1608

NR4A1在糖尿病肾病发病中作用的研究进展

吕文玥¹, 李金梦¹, 李含¹, 刘雷², 王娜^2*

1.济宁医学院临床医学院, 山东济宁 272029;
2.济宁医学院附属医院全科医学科, 山东济宁 272029

收稿日期:2022-12-30 修回日期:2023-05-04 出版日期:2023-10-05 发布日期:2023-10-05
通讯作者: *wangna19840906@163.com
基金资助:
济宁医学院贺林院士新医学临床转化工作站科研基金(JYHL2022FMS02)

Progress in the role of NR4A1 in the development of diabetic nephropathy

LYU Wenyue¹, LI Jinmeng¹, LI Han¹, LIU Lei², WANG Na^2*

1. Clinical Medical College,Jining Medical University,Jining 272029;
2. Department of General Practice,Affiliated Hospital of Jining Medical University,Jining 272029,China

Received:2022-12-30 Revised:2023-05-04 Online:2023-10-05 Published:2023-10-05
Contact: *wangna19840906@163.com

摘要/Abstract

摘要： NR4A1作为核受体亚家族的一员, 与糖脂代谢关键酶甘油激酶共同作用,可以降低血糖,升高血脂,维持糖脂平衡;而NR4A1的缺失又会导致肝脏糖脂代谢的紊乱。NR4A1参与维持氧化/抗氧化动态平衡,降低炎性反应,促进自噬等活动。因与糖尿病肾病等疾病发生关系密切,近年来NR4A1引起人们广泛关注。

关键词: NR4A1, 糖尿病肾病

Abstract: As a member of the nuclear receptor subfamily, NR4A1 works with glycerol kinase, a key glucose and lipid metabolism enzyme, to lower blood glucose and boost blood lipids and maintain glucose and lipid homeostasis, while NR4A1 deficiency leads to disruption of hepatic glucose and lipid metabolism. NR4A1 is involved in maintaining the dynamic balance of oxide and antioxidants, reducing inflammatory responses, and promoting autophagy, among other activities. Since NR4A1 is closely related to the occurrence of diabetic nephropathy and other diseases,it has aroused widespread concern in recent years.

Key words: NR4A1, diabetic nephropathy

中图分类号:

R587.2

吕文玥, 李金梦, 李含, 刘雷, 王娜. NR4A1在糖尿病肾病发病中作用的研究进展[J]. 基础医学与临床, 2023, 43(10): 1608-1611.

LYU Wenyue, LI Jinmeng, LI Han, LIU Lei, WANG Na. Progress in the role of NR4A1 in the development of diabetic nephropathy[J]. Basic & Clinical Medicine, 2023, 43(10): 1608-1611.

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参考文献

[1]Hiwa R, Brooks JF, Mueller JL, et al. NR4A nuclear receptors in T and B lymphocytes: gatekeepers of immune tolerance[J]. Immunol Rev, 2022, 307: 116-133.
[2]Tang G, Li S, Zhang C, et al. Clinical efficacies, underlying mechanisms and molecular targets of Chinese medicines for diabetic nephropathy treatment and management[J]. Acta Pharm Sin B, 2021, 11: 2749-2767.
[3]Zhou H, Wang J, Zhu P, et al. NR4A1 aggravates the cardiac microvascular ischemia reperfusion injury through suppressing FUNDC1-mediated mitophagy and promoting Mff-required mitochondrial fission by CK2α[J]. Basic Res Cardiol, 2018,113:23. doi:10.1007/s00395-018-0682-1.
[4]Pu Z, Yu T, Liu D, et al. NR4A1 enhances MKP7 expression to diminish JNK activation induced by ROS or ER-stress in pancreatic β cells for surviving[J]. Cell Death Discov, 2021, 7: 133.doi:10.1038/s41420-021-00521-0.
[5]Venu VKP, Saifeddine M, Mihara K, et al. Metformin prevents hyperglycemia-associated, oxidative stress-induced vascular endothelial dysfunction: essential role for the orphan nuclear receptor human nuclear receptor 4A1 (Nur77)[J]. Mol Pharmacol, 2021, 100: 428-455.
[6]Wang S, Zuo A, Jiang W, et al. JMJD1A/NR4A1 signaling regulates the procession of renal tubular epithelial interstitial fibrosis induced by AGEs in HK-2[J]. Front Med (Lausanne), 2022, 8: 807694.doi:10.3389/fmed.2021.807694.
[7]Chang L, Wang Q, Ju J, et al. Magnoflorine ameliorates inflammation and fibrosis in rats with diabetic nephropathy by mediating the stability of lysine-specific demethylase 3A[J]. Front Physiol, 2020, 11: 580406.doi:10.3389/fphys.2020.580406.
[8]Palumbo-Zerr K, Zerr P, Distler A, et al. Orphan nuclear receptor NR4A1 regulates transforming growth factor-β signaling and fibrosis[J]. Nat Med, 2015, 21: 150-158.
[9]Zhao Y, Wang C, Goel A. A combined treatment with melatonin and andrographis promotes autophagy and anticancer activity in colorectal cancer. Carcinogenesis, 2022,43:217-230. doi:10.1093/carcin/bgac008.
[10]Qin H, Gao F, Wang Y, et al. Nur77 promotes cigarette smoke-induced autophagic cell death by increasing the dissociation of Bcl2 from Beclin-1[J]. Int J Mol Med, 2019,44:25-36. doi:10.3892/ijmm.2019.4184.
[11]Zhu Y, Han XQ, Sun XJ, et al. Lactate accelerates vascular calcification through NR4A1-regulated mitochondrial fission and BNIP3-related mitophagy[J]. Apoptosis, 2020, 25: 321-340.
[12]鲍喜静, 李建英, 彭一, 等. 红花黄色素联合二甲双胍对早期糖尿病肾病患者凝血纤溶指标、微炎性反应及血管内皮功能的影响[J]. 河北医药, 2022, 44: 2451-2453+2457.
[13]Chen Y, Chen L, Yang T. Silymarin nanoliposomes attenuate renal injury on diabetic nephropathy rats via co-suppressing TGF-β/Smad and JAK2/STAT3/SOCS1 pathway[J]. Life Sci, 2021, 271: 119197.doi:10.1016/j.lfs.2021.119197.
[14]Qi M, He Y, Cheng Y, et al. Icariin ameliorates streptozocin-induced diabetic nephropathy through suppressing the TLR4/NF-κB signal pathway[J]. Food Funct, 2021, 12: 1241-1251.
[15]张靖, 党连生. 糖尿病肾病患者中血尿酸、IL-8和TNF-α水平的变化[J]. 包头医学院学报, 2022, 38: 60-63.
[16]Huang Q, Xue J, Zou R, et al. NR4A1 is associated with chronic low-grade inflammation in patients with type 2 diabetes[J]. Exp Ther Med, 2014, 8: 1648-1654.
[17]Peng S, Chen X, Chen S, et al. Phase separation of Nur77 mediates celastrol-induced mitophagy by promoting the liquidity of p62/SQSTM1 condensates[J]. Nat Commun, 2021, 12: 5989.doi:10.1038/s41467-021-26295-8.
[18]Han Y, Xiong S, Zhao H, et al. Lipophagy deficiency exacerbates ectopic lipid accumulation and tubular cells injury in diabetic nephropathy[J]. Cell Death Dis, 2021, 12: 1031. doi:10.1038/s41419-021-04326-y.
[19]Yang P, Hou P, Liu F, et al. Blocking PPARγ interaction facilitates Nur77 interdiction of fatty acid uptake and suppresses breast cancer progression[J]. Proc Natl Acad Sci U S A, 2020, 117: 27412-27422.
[20]Yuan R, Zhang W, Nie P, et al. Nur77 deficiency exacerbates macrophage NLRP3 inflammasome-mediated inflammation and accelerates atherosclerosis[J].Oxid Med Cell Longev, 2022;2022:2017815. doi:10.1155/2022/2017815.
[21]Zhang Y, Federation AJ, Kim S, et al. Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity[J]. J Clin Invest, 2018, 128: 4898-4911.

NR4A1在糖尿病肾病发病中作用的研究进展

Progress in the role of NR4A1 in the development of diabetic nephropathy

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