基础医学与临床 ›› 2022, Vol. 42 ›› Issue (10): 1539-1542.doi: 10.16352/j.issn.1001-6325.2022.10.1539

• 研究论文 • 上一篇    下一篇

不同放疗剂量同步化疗对食管癌疗效及不良反应的比较

任孟先1*, 梁伟2, 臧刘兵1, 魏雪蕊1   

  1. 1.太和县人民医院 放射治疗科,安徽 阜阳 236600;
    2.安徽医科大学第一附属医院 放射治疗科,安徽 合肥 230031
  • 收稿日期:2022-04-20 修回日期:2022-07-21 出版日期:2022-10-05 发布日期:2022-09-23
  • 通讯作者: * 1328108798@qq.com
  • 基金资助:
    安徽省科技重大专项 (202103a0720011)

Comparison of the effects and adverse reactions of different radiotherapy doses and concurrent chemotherapy for esophageal cancer

REN Meng-xian1*, LIANG Wei2, ZANG Liu-bing1, WEI Xue-rui1   

  1. 1. Department of Radiotherapy,Taihe County People's Hospital,Fuyang 236600;
    2. Department of Radiotherapy, the First Affiliated Hospital of Anhui Medical University,Hefei 230031,China
  • Received:2022-04-20 Revised:2022-07-21 Online:2022-10-05 Published:2022-09-23
  • Contact: * 1328108798@qq.com

摘要: 目的 比较接受不同放疗剂量同步化疗的食管癌治疗疗效及不良反应发生情况。方法 研究对象为太和县人民医院放疗科收治的开展放化疗的食管癌患者,入院时间为2020年3月至2022年3月,入选患者共40例,利用随机数表法分组分为对照组(高剂量组,n=20)与实验组(低剂量组,n=20)。对比分析两组的疗效、不良反应及预后。结果 实验组经低剂量放疗同步化疗后,其临床疗效略高于对照组,差异不明显。在SF-36评分与KPS评分上,两组没有明显差异。在不良反应总发生率上,实验组低于对照组(P<0.05)。结论 对食管癌患者实施放疗同步化疗的效果良好,但低剂量放疗发生的不良反应较小,安全性更高。

关键词: 食管癌, 放疗, 化疗, 不良反应

Abstract: Objective To compare the efficacy and adverse reactions of esophageal cancer patients treated with different radiotherapy doses and concurrent chemotherapy. Methods The subjects of this study were esophageal cancer patients receiving radiotherapy and chemotherapy in Taihe County People's Hospital from March 2020 to March 2022. A total of 40 patients were enrolled and divided into control group (high-dose group, n=20) and experimental group (low-dose group, n=20) by random number table method. The efficacy, adverse reactions and prognosis of the two groups were compared and analyzed. Results After low-dose radiotherapy and chemotherapy, the clinical efficacy of the experimental group was slightly higher than that of the control group, but the difference was not significant. There was no significant difference in SF-36 score and KPS score between the two groups. The total incidence of adverse reaction in experimental group was lower than that in control group(P<0.05). Conclusions Radiotherapy combined with chemotherapy has a good effect on patients with esophageal cancer and low dose radiotherapy has less adverse reactions and higher safety.

Key words: esophageal cancer, radiation therapy, chemotherapy, adverse reaction

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