肾小球系膜细胞增殖在糖尿病肾病肾小球硬化中作用的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (10): 1510-1513.

肾小球系膜细胞增殖在糖尿病肾病肾小球硬化中作用的研究进展

孙凤起, 武韧, 常贵全, 李鸿珠^*

哈尔滨医科大学基础医学院病理生理学教研室,黑龙江哈尔滨 150086

收稿日期:2020-07-16 修回日期:2020-11-19 发布日期:2021-09-29
通讯作者: *hongzhuli61@163.com
基金资助:
国家自然科学基金(81770486)

Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy

SUN Feng-qi, WU Ren, CHANG Gui-quan, LI Hong-zhu^*

Department of Pathophysiology, School of Basic Medicine,Harbin Medical University, Harbin 150086, China

Received:2020-07-16 Revised:2020-11-19 Published:2021-09-29
Contact: *hongzhuli61@163.com

摘要/Abstract

摘要： 糖尿病肾病(DN)是糖尿病患者常见的微血管慢性并发症。系膜细胞(MC)是肾小球内主要的细胞成分。高糖刺激可通过降低细胞内源性硫化氢的浓度、激活转化生长因子β(TGF-β)超家族和影响长链非编码RNA(LncRNA)水平促进系膜细胞增殖。系膜细胞的异常激活在糖尿病肾小球硬化的进程中起重要推动作用。

关键词: 糖尿病肾病, 肾小球硬化, 高糖, 系膜细胞

Abstract: Diabetic nephropathy is a common chronic microvascular complication in diabetic patients. Mesangial cell is the main cell type in glomeruli. High glucose stimulation can promote mesangial cell proliferation by reducing endogenous hydrogen sulfide concentration, activating transforming growth factor-β superfamily and influencing long non-coding RNA level. Abnormal activation of mesangial cells plays an important role in the pathogenesis of diabetic glomerulosclerosis.

Key words: diabetic nephropathy, glomerulosclerosis, high glucose, mesangial cell

中图分类号:

R587.1

孙凤起, 武韧, 常贵全, 李鸿珠. 肾小球系膜细胞增殖在糖尿病肾病肾小球硬化中作用的研究进展[J]. 基础医学与临床, 2021, 41(10): 1510-1513.

SUN Feng-qi, WU Ren, CHANG Gui-quan, LI Hong-zhu. Research progress on the role of glomerular mesangial cell proliferation in glomerulosclerosis of diabetic nephropathy[J]. Basic & Clinical Medicine, 2021, 41(10): 1510-1513.

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