细胞自噬与肝细胞癌的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (10): 1514-1517.

细胞自噬与肝细胞癌的研究进展

吴娜, 王东, 白咸勇^*

滨州医学院基础医学院组织学与胚胎学教研室, 山东烟台 264003

收稿日期:2020-07-16 修回日期:2020-11-20 发布日期:2021-09-29
通讯作者: *xybai1963@126.com
基金资助:
国家自然科学基金(81073123)

Progress in research on autophagy and hepatocellular carcinoma

WU Na, WANG Dong, BAI Xian-yong^*

Department of Histology and Embryology, College of Basic Medicine, Binzhou Medical University, Yantai 264003,China

Received:2020-07-16 Revised:2020-11-20 Published:2021-09-29
Contact: *xybai1963@126.com

摘要/Abstract

摘要： 细胞自噬是真核生物维持内环境稳态的一种保护性机制。同时,在维持肿瘤细胞存活及能量代谢方面具有重要作用,并通过不同机制影响肝癌的治疗效果。如肝细胞通过自噬维持肝内稳态,自噬引起肝癌细胞产生耐药性,以及自噬抑制剂和天然提取物通过自噬途径发挥抗肝癌作用。对深入探讨自噬在肝癌预防和治疗中的调控具有重大意义。

关键词: 自噬, 肝细胞癌, 治疗, 自噬相关基因

Abstract: Autophagy is a protective mechanism for eukaryotes to maintain homeostasis. Meanwhile, it plays an important role in maintaining the survival and energy metabolism of tumor cells, and also have some impacts on the therapeutic effect of liver cancer through different mechanisms, for example autophagy maintains liver cells homeostasis, causes drug resistance of liver cancer cells. The autophagy inhibitors or natural extracts play a role of resistance to liver cancer through autophagy pathways. It is a great significance to study the regulation mechanisms of autophagy in the prevention and treatment of hepatocellular carcinoma.

Key words: autophagy, hepatocellular carcinoma, therapy, autophagy related gene

中图分类号:

R735.7

吴娜, 王东, 白咸勇. 细胞自噬与肝细胞癌的研究进展[J]. 基础医学与临床, 2021, 41(10): 1514-1517.

WU Na, WANG Dong, BAI Xian-yong. Progress in research on autophagy and hepatocellular carcinoma[J]. Basic & Clinical Medicine, 2021, 41(10): 1514-1517.

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