妊娠期代谢综合征对母亲健康及后代生长发育影响的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (10): 1518-1522.

妊娠期代谢综合征对母亲健康及后代生长发育影响的研究进展

孙影, 董世云^*

哈尔滨医科大学基础医学院病理生理学教研室, 黑龙江哈尔滨 150086

收稿日期:2020-07-26 修回日期:2020-11-20 发布日期:2021-09-29
通讯作者: *sydongcrystal@126.com
基金资助:
国家自然科学基金(81300164)

Research progress on the effects of gestational metabolic syndrome on maternal health and offspring growth and development

SUN Ying, DONG Shi-yun^*

Department of Pathophysiology, School of Basic Medicine, Harbin Medical University, Harbin 150086, China

Received:2020-07-26 Revised:2020-11-20 Published:2021-09-29
Contact: *sydongcrystal@126.com

摘要/Abstract

摘要： 妊娠期女性为满足妊娠过程母体和胎儿的需要,体内各系统发生不同程度的改变。但由于个体的差异,部分妊娠期女性会出现2型糖尿病(T2D)、脂质紊乱和高血压等代谢性异常,影响母亲健康及后代神经及心血管等系统的发育。因此,控制各种代谢异常有利于改善妊娠结局。

关键词: 妊娠糖尿病, 胰岛素抵抗, 代谢综合征

Abstract: In order to meet the needs of the mother and fetus during pregnancy, the various systems in the body have more or less changed. However, because of individual differences,some pregnant women may suffer from metabolic syndrome such as type 2 diabetes(T2D) mellitus, lipid disorder, and hypertension, which will affect the health of mothers and the development of nervous and cardiovascular systems of their offspring. Therefore, controlling various metabolic abnormalities is beneficial to improve pregnancy outcomes.

Key words: gestational diabetes, insulin resistance, metabolic syndrome

中图分类号:

孙影, 董世云. 妊娠期代谢综合征对母亲健康及后代生长发育影响的研究进展[J]. 基础医学与临床, 2021, 41(10): 1518-1522.

SUN Ying, DONG Shi-yun. Research progress on the effects of gestational metabolic syndrome on maternal health and offspring growth and development[J]. Basic & Clinical Medicine, 2021, 41(10): 1518-1522.

参考文献

[1]Christina M, Dieli C, Kerry SC, et al. Effects of aerobic and resistance exercise on metabolic syndrome, sarcopenic obesity, and circulating biomarkers in overweight or obese survivors of breast cancer: a randomized controlled trial [J]. J Clin Oncol, 2018, 36:875-883.
[2]Savage DB, Watson L, Carr K, et al. Accumulation of saturated intramyocellular lipid is associated with insulin resistance [J]. J Lipid Res, 2019, 60:1323-1332.
[3]Justyna TC, Jacek S, Julia ZS, et al. Influence of glycemic control on coagulation and lipid metabolism in pregnancies complicated by pregestational and gestational diabetes mellitus [J]. Adv Med Biol, 2019, 1176:81-88.
[4]Wen J, Liu X. Effect of magnesium sulfate combined with phentolamine and nifedipine for gestational hypertension and serum Levels of LIF and apelin [J]. J Coll Physicians Surg Pak, 2019, 29:231-234.
[5]Katja M, Villa PM, Jaakko M, et al. Prediction of pre-eclampsia and its subtypes in high-risk cohort: hyperglycosylated human chorionic gonadotropin in multivariate models [J]. BMC Pregnancy Childbirth, 2018, 18:279-304.
[6]Bao W, Dar S, Zhu Y, et al. Plasma concentrations of lipids during pregnancy and the risk of gestational diabetes mellitus: a longitudinal study [J]. J Diabetes, 2018, 10:487-495.
[7]Hughes RC, Rowan J, Williman J, et al. Prediabetes in pregnancy, can early intervention improve outcomes? A feasibility study for a parallel randomised clinical trial [J]. BMJ Open, 2018, 8:e018493. doi: 10.1136/bmjopen-2017-018493.
[8]Michelle O'Brien, Baczyk D, Kingdom JC, et al. Endothelial dysfunction in severe preeclampsia is mediated by soluble factors, rather than extracellular vesicles [J]. Sci Rep, 2017, 7:5887-5915.
[9]Hjort L, Martino D, Grunnet LG, et al. Gestational diabetes and maternal obesity are associated with epigenome-wide methylation changes in children [J]. JCI Insight, 2018, 3:e122572.doi:10.1172./jci.insight.122572.
[10]Shiva K, Fatemeh Y, Fereydoun S, et al. Cardamom supplementation improves inflammatory and oxidative stress biomarkers in hyperlipidemic, overweight, and obese pre-diabetic women: a randomized double-blind clinical trial [J]. J Sci Food Agric, 2017, 97:5296-5301.
[11]Rout M, Sajitha LS. Molecular and disease association of gestational diabetes mellitus affected mother and placental datasets reveal a strong link between insulin growth factor (IGF) genes in amino acid transport pathway: a network biology approach [J]. J Cell Biochem, 2019, 120:1577-1587.
[12]Marioni G, Ottaviano G, Lovato A, et al. Expression of maspin tumor suppressor and mTOR in laryngeal carcinoma [J]. Am J Otolaryngol, 2020, 41:102322-102328.
[13]Gupta MB, Majida AS, Karen N, et al. IUGR is associated with marked hyperphosphorylation of decidual and maternal plasma IGFBP-1 [J]. J Clin Endocrinol Metab, 2019, 104:408-422.
[14]Babadi M, Khorshidi A, Aghadavood E, et al. The effects of probiotic supplementation on genetic and metabolic profiles in patients with gestational diabetes mellitus: a randomized, double-blind, placebo-controlled trial [J].Probiotics Antimicro, 2019, 11:1227-1235.
[15]Salvesen, Øyvind S, Juliusson PB, et al. Intrauterine metformin exposure and offspring cardiometabolic risk factors (PedMet study): a 5-10 year follow-up of the PregMet randomised controlled trial [J]. Lancet Child Adolesc Health, 2019, 3:166-174.
[16] Peng TR, Wu TW, Chao YC, et al. Effect of probiotics on the glucose levels of pregnant women: a meta-analysis of randomized controlled trials [J]. Medicina, 2018, 54:77-98.
[17]Huerta CM, Donovan JP. Gestational diabetes triggers oxidative stress in hippocampus and cerebral cortex and cognitive behavior modifications in rat offspring: age-and sex-dependent effects [J]. Nutrients, 2020, 12:376-410.
[18]Pazhohan A, Rezaee MM, Pazhohan N, et al. Association of first-trimester maternal lipid profiles and triglyceride-glucose index with the risk of gestational diabetes mellitus and large for gestational age newborn [J]. J Matern Fetal Neonatal Med, 2019, 32:1167-1175.
[19]Gázquez A, Uhl O, Ruíz PM, et al. Placental lipid droplet composition: effect of a lifestyle intervention(UPBEAT) in obese pregnant women [J]. Biochim Biophy Acta Mo Cell Biol Lipids, 2018, 1863:998-1005.
[20]Louise GG, Susanne H, Line H, et al. Adiposity, Dysmetabolic traits, and earlier onset of female puberty in adolescent offspring of women with gestational diabetes mellitus: a clinical study within the danish national birth cohort [J]. Diabetes Care, 2017, 40:1746-1755.
[21]Vega M, Mauro M, Williams Z, et al. Direct toxicity of insulin on the human placenta and protection by metformin [J]. Fertil Steril, 2019, 111:489-496.