HIF-1介导的自噬在心脏疾病中的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (8): 1186-1189.

HIF-1介导的自噬在心脏疾病中的研究进展

张刘杰¹, 李静², 吴博^1*

1.哈尔滨医科大学基础医学院病理生理学教研室,黑龙江哈尔滨 150086;
2.哈尔滨医科大学附属第二医院老年病科, 黑龙江哈尔滨 150081

收稿日期:2019-12-16 修回日期:2020-03-26 出版日期:2021-08-05 发布日期:2021-07-21
通讯作者: *wubow2012@aliyun.com
基金资助:
国家自然科学基金青年科学基金(81400210);黑龙江省教育厅科学技术研究项目(12541335);黑龙江省留学归国人员科学基金(LC201433)

Research progress of HIF-1 mediated autophagy in cardiac diseases

ZHANG Liu-jie¹, LI Jing², WU Bo^1*

1. Department of Pathophysiology, School of Basic Medical Sciences, Harbin 150086;
2. Department of Geriatrics, the Second Affiliated Hospital, Harbin Medical University, Harbin 150081, China

Received:2019-12-16 Revised:2020-03-26 Online:2021-08-05 Published:2021-07-21
Contact: *wubow2012@aliyun.com

摘要/Abstract

摘要： 低氧诱导因子1(HIF-1)通过调控靶基因表达维持机体供氧和需氧平衡,保持细胞氧稳态,并调节缺血心肌自噬水平,其靶基因表达产物BNIP3蛋白参与此调节过程。

关键词: 低氧诱导因子1, 低氧, 自噬, 心脏

Abstract: Hypoxia-inducible factor 1 (HIF-1) regulates the expression of target genes to keep the balance between oxygen supply and oxygen consumption, maintains oxygen homeostasis. HIF-1 regulates autophagy in the cardiovascular system, which involves the HIF target gene BNIP3.

Key words: hypoxia-inducible factor 1, hypoxia, autophagy, cardiac

中图分类号:

R542.2

张刘杰, 李静, 吴博. HIF-1介导的自噬在心脏疾病中的研究进展[J]. 基础医学与临床, 2021, 41(8): 1186-1189.

ZHANG Liu-jie, LI Jing, WU Bo. Research progress of HIF-1 mediated autophagy in cardiac diseases[J]. Basic & Clinical Medicine, 2021, 41(8): 1186-1189.

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