基础医学与临床 ›› 2017, Vol. 37 ›› Issue (11): 1629-1633.
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文钟1,谢文光2,周京国3
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摘要： 钠依赖性磷酸转运蛋白由溶质载体家族17基因编码，编码基因位于6号染色体上,是人体重要的以有机阴离子为底物的转运蛋白，在肾脏等组织中表达。其中钠依赖性磷酸转运蛋白1、3和4有转运尿酸的功能，功能异常会导致尿酸排泄减少，从而引起高尿酸血症，甚至诱发痛风。
关键词: 尿酸, 高尿酸血症, 痛风, 钠依赖性磷酸转运蛋白, 单核苷酸多态性
Abstract: Sodium-dependent phosphate cotransporter is encoded by the solute carrier family 17 gene. The gene is located on chromosome 6 and is an important transporter of the organic anion as the substrate and is expressed in kidney and other tissues.Among them, the sodium-dependent phosphate transporter type 1, 3, and 4 have the function of transferring uric acid, and abnormal function can lead to the decrease of uric acid excretion, which can cause hyperuricemia and even induce gout.
Key words: uric acid, hyperuricemia, gout, sodium-dependent phosphate cotransporter, genetic polymorphism
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R589.7
文钟 谢文光 周京国. 钠依赖性磷酸转运蛋白在痛风/高尿酸血症中的研究进展[J]. 基础医学与临床, 2017, 37(11): 1629-1633.
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