饮食治疗痛风与高尿酸血症的研究进展

doi:10.16352/j.issn.1001-6325.2025.03.0382

摘要/Abstract

摘要： 本文讨论了营养学针对肠道的抗高尿酸血症(HUA)机制,例如肠道菌群如何促进嘌呤和尿酸(UA)的分解代谢、肠道菌群及如何影响血尿酸水平,还总结了针对肠道具有降尿酸作用的益生菌和益生元的作用,为进一步的研究提供参考和指导。此外,本文回顾各种饮食对血尿酸的影响,如预防与控制高血压饮食模式(DASH)饮食、地中海饮食和低嘌呤饮食, 以及个别食物包括酒精、咖啡、茶、樱桃、乳制品、果糖和维生素C等对高尿酸血症和痛风发作的影响。

关键词: 痛风, 高尿酸血, 饮食因素, 营养学, 体质量指数

Abstract: This review briefs the anti-hyperuricemia(HUA) mechanism of nutrition targeting the gut, such as the gut microbiota promoting the catabolism of purine and uric acid(UA), and increased its metabolites like uric acid. The review also summarizes the probiotics and prebiotics that have the effect of lowering uric acid targeting at the gut, providing reference and guidance for further research. In addition, this paper reviews the effects of various diets, such as the dietary approaches to stop hypertension(DASH) diet, the Mediterranean diet, and the low-purine diet, as well as the effects of individual foods including alcohol, coffee and tea, cherries, dairy products, fructose, and vitamin C on hyperuricemia and gout outcomes.

Key words: gout, hyperuricemia, dietary factor, nutrition, body mass index

中图分类号:

金磊, 吴茜茜, 张晓敏, 郭洁, 王锋. 饮食治疗痛风与高尿酸血症的研究进展[J]. 基础医学与临床, 2025, 45(3): 382-389.

JIN Lei, WU Qianqian, ZHANG Xiaomin, GUO Jie, WANG Feng. Progress on dietary therapy for gout and hyperuricemia[J]. Basic & Clinical Medicine, 2025, 45(3): 382-389.

参考文献

[1] Liu K, Yao Y, Chen W, et al. Modifiable risk factors and incidence of gout: estimation of population attributable fraction in the US[J]. Semin Arthritis Rheum, 2022, 55:152040. doi: 10.1016/j.semarthrit.2022.152040.
[2] Zhang J, Jin C, Ma B, et al. Global, regional and national burdens of gout in the young population from 1990 to 2019: a population-based study[J]. RMD Open, 2023, 9:e003025. doi: 10.1136/rmdopen-2023-003025.
[3] Wan H, Han J, Tang S, et al. Comparisons of protective effects between two sea cucumber hydrolysates against diet induced hyperuricemia and renal inflammation in mice[J]. Food Function, 2020,29,11:1074-1086. doi: 10.1039/c9fo02425e.
[4] Liu G, X. F. Chen, X. Lu, et al. Sunflower head enzymatic hydrolysate relives hyperuricemia by inhibiting crucial proteins (xanthine oxidase, adenosine deaminase, uric acid transporter1) and restoring gut microbiota in mice[J]. J Funct Foods, 2020, 72:104055. doi: 10.1016/j.jff.2020.104055.
[5] Juraschek SP, Yokose C, McCormick N, et al. Effects of dietary patterns on serum urate: results from a randomized trial of the effects of diet on hypertension[J]. Arthritis Rheumatol, 2021,73:1014-1020. doi: 10.1002/art.41614.
[6] Tang O, Miller ER 3rd, Gelber AC, et al. DASH diet and change in serum uric acid over time[J]. Clin Rheumatol, 2017,36:1413-1417. doi: 10.1007/s10067-017-3613-x.
[7] Yi K, Cui S, Tang M, et al. Adherence to DASH dietary pattern and its association with incident hyperuri-cemia risk: a prospective study in Chinese community residents[J]. Nutrients, 2022, 14:4853. doi: 10.3390/nu14224853.
[8] FitzGerald JD, Dalbeth N, Mikuls T, et al. 2020 American College of Rheumatology Guideline for the Management of Gout[J]. Arthritis Care Res (Hoboken), 2020, 72:744-760. doi: 10.1002/acr.24180.
[9] Hidalgo-Mora JJ, García-Vigara A, Sánchez-Sánchez ML, et al. The mediterranean diet: a historical perspec-tive on food for health[J]. Maturitas, 2020,132:65-69. doi: 10.1016/j.maturitas.
[10] Estruch R, Ros E, Salas-Salvadó J, et al. Primary prevention of cardiovascular disease with a mediterranean diet supplemented with extra-virgin olive oil or nuts[J]. N Engl J Med, 2018, 378:e34. doi: 10.1056/NEJMoa1800389.
[11] Yokose C, McCormick N, Rai SK, et al. Effects of low-fat, mediterranean, or low-carbohydrate weight loss diets on serum urate and cardiometabolic risk factors: a secondary analysis of the dietary intervention randomized controlled trial (DIRECT). [J]. Diabetes Care, 2020,,43:2812-2820. doi: 10.2337/dc20-1002.
[12] Major TJ, Topless RK, Dalbeth N, et al. Evaluation of the diet wide contribution to serum urate levels: Meta-analysis of population based cohorts[J]. BMJ, 2018, 363:k3951. doi: 10.1136/bmj.k3951..
[13] Danve A, Sehra ST, Neogi T. Role of diet in hyperuricemia and gout[J]. Best Pract Res Clin Rheumatol, 2021, 35:101723. doi: 10.1016/j.berh.2021.101723.
[14] Choi HK, McCormick N, Lu N, et al. Population impact attributable to modifiable risk factors for hyperuricemia[J]. Arthritis Rheumatol, 2020, 72:157-165. doi: 10.1002/art.41067.
[15] Caprio M, Infante M, Moriconi E,et al. Very-low-calorie ketogenic diet (VLCKD) in the management of metabolic diseases: systematic review and consensus statement from the Italian Society of Endocrinology (SIE)[J]. J Endocrinol Invest, 2019, 42:1365-1386. doi: 10.1007/s40618-019-01061-2.
[16] Muscogiuri G, Barrea L, Laudisio D, et al. The management of very low-calorie ketogenic diet in obesity outpatient clinic: a practical guide[J]. J Transl Med, 2019, 17:356. doi: 10.1186/s12967-019-2104-z.
[17] Preda A, Carbone F, Tirandi A, et al. Obesity pheno-types and cardiovascular risk: from pathophysiology to clinical management[J]. Rev Endocr Metab Disord, 2023,24:901-919. doi: 10.1007/s11154-023-09813-5.
[18] Ostfeld RJ. Definition of a plant-based diet and overview of this special issue[J]. J Geriatr Cardiol, 2017, 14:315. doi: 10.11909/j.issn.1671-5411.2017.05.008.
[19] Teng GG, Pan A, Yuan JM, et al. Food sources of protein and risk of incident gout in the singapore chinese health study[J]. Arthritis Rheumatol, 2015,67:1933-42. doi: 10.1002/art.39115.
[20] Mao D, Feng J, Zhou Y, et al. Analysis of different plant- and animal-based dietary patterns and their relationship with serum uric acid levels in Chinese adults[J]. Nutr J, 2023, 22:53. doi: 10.1186/s12937-023-00885-2.
[21] Flynn TJ, Cadzow M, Dalbeth N, et al. Positive association of tomato consumption with serum urate: support for tomato consumption as an anecdotal trigger of gout flares[J]. BMC Musculoskelet Disord,2015,16:196. doi: 10.1186/s12891-015-0661-8.
[22] Martin KR, Coles KM. Consumption of 100% tart cherry juice reduces serum urate in overweight and obese Adults[J]. Curr Dev Nutr, 2019,3:nzz011. doi: 10.1093/cdn/nzz011.
[23] Collins MW, Saag KG, Singh JA. Is there a role for cherries in the management of gout?[J]. Ther Adv Musculoskelet Dis, 2019,11:1759720X19847018. doi: 10.1177/1759720X19847018.
[24] Han L, Li R, Lu J,et al. Association of the quantity, duration, and type of alcohol consumption on the develop-ment of gouty tophi[J]. Arthritis Care Res (Hoboken), 2023, 75:1079-1087. doi: 10.1002/acr.24968.

编辑推荐 0

Metrics

阅读次数

全文

HTML			PDF

最新录用	在线预览	正式出版	最新录用	在线预览	正式出版
0	0	0	0	0	20

	来源	本网站

	次数	20
	比例	100%

摘要

最新录用	在线预览	正式出版

0	0	61

	来源	本网站

	次数	61
	比例	100%