基础医学与临床 ›› 2017, Vol. 37 ›› Issue (1): 133-137.
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丁博月,韩春
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摘要： 肠道干细胞分为两种，一个是表达Lgr5基底柱状干细胞，其表达与疾病分期有关，调控着细胞周期不断更替；另一个是+4干细胞，与肿瘤异质性有关，表达Bmi1使细胞周期停滞，此外还包括：Musashi1(Msi1)。多项研究表明在结直肠癌中以上标志物是高表达的，并可作用于Notch和经典Wnt信号通路促进肿瘤的发生和进展。
关键词: 结直肠癌, Lgr5, Bmi1, Musashi1（Msi1）, Wnt信号通路, Notch信号通路
Abstract: Colorectal stem cells have many markers,including Lgr5, its expression is associated with stage of disease, also regulating the cell cycle which the +4 stem cell, which is associated with tumor heterogeneity , also expressed Bmi1, arresting cell cycle.Besides there isMusashi1(Msi1).Many studies show that those markers are high expression in colorectal cancer, which activate Notch and Wnt signaling pathway, and can promote the progress of tumor.
Key words: Colorectal cancer, Lgr5, Bmi1, Musashi1（Msi1）, Wnt signal, Notch signal.
丁博月 韩春. 结直肠癌干细胞表面标志物和信号通路研究进展[J]. 基础医学与临床, 2017, 37(1): 133-137.
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