NETs与急性呼吸窘迫综合征的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (7): 1047-1051.

NETs与急性呼吸窘迫综合征的研究进展

王行行, 王导新^*

重庆医科大学附属第二医院呼吸与危重症医学科, 重庆 400010

收稿日期:2020-07-18 修回日期:2020-09-30 出版日期:2021-07-05 发布日期:2021-06-17
通讯作者: *wangdaoxin1@163.com
基金资助:
国家自然科学基金(81670071)

Research advances in NETs and acute respiratory distress syndrome

WANG Hang-hang, WANG Dao-xin^*

Department of Respiratory and Critical Care Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010,China

Received:2020-07-18 Revised:2020-09-30 Online:2021-07-05 Published:2021-06-17
Contact: *wangdaoxin1@163.com

摘要/Abstract

摘要： 中性粒细胞胞外诱捕网(NETs)是一种新型抗菌形式,但过量的NETs也能通过直接或者间接的方式造成肺损伤,促进炎性反应。NETs与急性呼吸窘迫综合征(ARDS)病情进展息息相关,可为其治疗带来新的线索。

关键词: 中性粒细胞胞外诱捕网, 急性呼吸窘迫综合征, 发病机制

Abstract: Neutrophil extracellular traps (NETs) are novel antibacterial method, which in overdose may directly or indirectly cause lung injury and promote inflammatory responses. NETs are closely related to the progression of acute respiratory distress syndrome (ARDS) and may provide new clues for the treatment of ARDS.

Key words: neutrophil extracellular traps, acute respiratory distress syndrome, pathogenesis

中图分类号:

R563.8

王行行, 王导新. NETs与急性呼吸窘迫综合征的研究进展[J]. 基础医学与临床, 2021, 41(7): 1047-1051.

WANG Hang-hang, WANG Dao-xin. Research advances in NETs and acute respiratory distress syndrome[J]. Basic & Clinical Medicine, 2021, 41(7): 1047-1051.

参考文献

[1]Neubert E, Senger-Sander SN, Manzke VS, et al. Serum and serum albumin inhibit in vitro formation of neutrophil extracellular traps (NETs)[J].Front Immunol,2019,10:12. doi: 10.3389/fimmu.2019.00012.
[2]Kenny EF, Herzig A, Krüger R, et al. Diverse stimuli engage different neutrophil extracellular trap pathways[J].Elife,2017,6:e24437. doi: 10.7554/eLife.24437.
[3]Luo L, Zhang S, Wang Y, et al. Proinflammatory role of neutrophil extracellular traps in abdominal sepsis[J].Am J Physiol Lung Cell Mol Physiol,2014,307:L586-L596.
[4]Shrestha B, Ito T, Kakuuchi M, et al. Recombinant thrombomodulin suppresses histone-induced neutrophil extracellular trap formation[J].Front Immunol,2019,10:2535. doi: 10.3389/fimmu.2019.02535.
[5]Pylaeva E, Bordbari S, Spyra I, et al. Detrimental effect of type I IFNs during acute lung infection with pseudo-monas aeruginosa is mediated through the stimulation of neutrophil NETosis[J].Front Immunol,2019,10:2190. doi: 10.3389/fimmu.2019.02190.
[6]Ebrahimi F, Giaglis S, Hahn S, et al. Markers of neutrophil extracellular traps predict adverse outcome in community-acquired pneumonia: secondary analysis of a randomised controlled trial[J].Eur Respir J,2018,51:1701389. doi: 10.1183/13993003.01389-2017.
[7]Lee KH, Cavanaugh L, Leung H, et al. Quantification of NETs-associated markers by flow cytometry and serum assays in patients with thrombosis and sepsis[J].Int J Lab Hematol,2018,40:392-399.
[8]Liu L, Mao Y, Xu B, et al. Induction of neutrophil extracellular traps during tissue injury: Involvement of STING and Toll-like receptor 9 pathways[J].Cell Prolif,2019,52:e12579. doi: 10.1111/cpr.12579.
[9]Song C, Li H, Li Y, et al. NETs promote ALI/ARDS inflammation by regulating alveolar macrophage polarization[J].Exp Cell Res,2019,382:111486. doi: 10.1016/j.yexcr.2019.06.031.
[10]McDonald B, Davis RP, Kim SJ, et al. Platelets and neutrophil extracellular traps collaborate to promote intravascular coagulation during sepsis in mice[J]. Blood,2017,129:1357-1367.
[11]郑玥,郑行,祝元锋,等.白蛋白对脂多糖诱导中性粒细胞胞外诱捕网生成的抑制作用[J].免疫学杂志,2020,36:397-403.
[12]Sondo E, Bertelli R, Pesce E, et al, High-content screening identifies vanilloids as a novel class of inhibitors of NET formation[J].Front Immunol,2019,10:963. doi: 10.3389/fimmu.2019.00963.
[13]Deng Q, Pan B, Alam HB, et al. Citrullinated histone H3 as a therapeutic target for endotoxic shock in mice[J].Front Immunol,2020,10:2957. doi: 10.3389/fimmu.2019.02957.
[14]Pottecher J, Noll E, Borel M, et al. Protocol for TRAUMADORNASE: a prospective, randomized, multicentre, double-blinded, placebo-controlled clinical trial of aerosolized dornase alfa to reduce the incidence of moderate-to-severe hypoxaemia in ventilated trauma patients[J].Trials,2020,21:274. doi: 10.1186/s13063-020-4141-6.
[15]Okeke EB, Louttit C, Fry C, et al. Inhibition of neutrophil elastase prevents neutrophil extracellular trap formation and rescues mice from endotoxic shock[J].Biomaterials,2020,238:119836. doi: 10.1016/j.biomaterials.2020.119836.
[16]Pedrazza L, Cunha AA, Luft C, et al. Mesenchymal stem cells improves survival in LPS-induced acute lung injury acting through inhibition of NETs formation[J].J Cell Physiol,2017,232:3552-3564.
[17]Neumann A, Papareddy P, Westman J, et al. Immunoregulation of neutrophil extracellular trap formation by endothelial-derived p33 (gC1q Receptor)[J].J Innate Immun,2018,10:30-43.
[18]Zlatina K, Lütteke T, Galuska SP. Individual impact of distinct polysialic acid chain lengths on the cytotoxicity of histone H1, H2A, H2B, H3 and H4[J].Polymers (Basel),2017,9:720. doi: 10.3390/polym9120720.
[19]Bornhöfft KF, Viergutz T, Kühnle A, et al. Nanoparticles equipped with α2,8-linked sialic acid chains inhibit the release of neutrophil extracellular traps[J].Nanomaterials (Basel),2019,9:610. doi: 10.3390/nano9040610.
[20]Zlatina K, Saftenberger M, Kühnle A, et al. Polysialic acid in human plasma can compensate the cytotoxicity of histones[J].Int J Mol Sci,2018,19:1679. doi: 10.3390/ijms19061679.
[21]Arroyo R, Khan MA, Echaide M, et al. SP-D attenuates LPS-induced formation of human neutrophil extracellular traps (NETs), protecting pulmonary surfactant inactiva-tion by NETs[J].Commun Biol,2019,2:470. doi: 10.1038/s42003-019-0662-5.
[22]Wang YP, Guo Y, Wen PS, et al. Three ingredients of safflower alleviate acute lung injury and inhibit NET release induced by lipopolysaccharide[J].Mediators Inflamm,2020,2020:2720369. doi: 10.1155/2020/2720369.
[23]Shi Y, Liu T, Nieman DC, et al. Aerobic exercise attenuates acute lung injury through NET inhibition[J].Front Immunol,2020,11:409. doi: 10.3389/fimmu.2020.00409.