SIRT3介导的线粒体功能和代谢调控机制在2型糖尿病中作用的研究进展

摘要/Abstract

摘要： 2型糖尿病(T2DM)在临床上发病率高,目前缺乏有效治疗手段。线粒体损伤和代谢紊乱是T2DM最重要的病理生理学表现,定位于线粒体的SIRT3对于维持线粒体功能及细胞代谢稳态至关重要。研究表明SIRT3能通过调节呼吸酶活性、抗氧化应激、促进线粒体自噬及葡萄糖摄取等途径,减缓或抑制T2DM及其并发症的发生发展。

关键词: SIRT3, 线粒体, 代谢, 2型糖尿病

Abstract: Diabetes mellitus type 2(T2DM) has a high morbidity because there is no specific treatment. Mitochondrial injury and metabolic disorder are the most important pathophysiological manifestations of T2DM. So it is essential to maintain mitochondrial function and cell metabolic homeostasis. Mitochondrial deacetylase silence information regulator 3 (SIRT3) is crucial for the regulation of respiratory enzymes, for antagonizing oxidative stress and promoting mitochondrial autophagy as well as glucose uptake.

Key words: SIRT3, mitochondria, metabolism, diabetes mellitus type 2

中图分类号:

R363

杨静, 李民. SIRT3介导的线粒体功能和代谢调控机制在2型糖尿病中作用的研究进展[J]. 基础医学与临床, 2021, 41(12): 1828-1832.

YANG Jing, LI Min. Advances in the role of SIRT3-mediated mitochondrial function and metabolic regulation in diabetes mellitus type 2[J]. Basic & Clinical Medicine, 2021, 41(12): 1828-1832.

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