非甾体抗炎剂调控免疫细胞的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (12): 1833-1837.

非甾体抗炎剂调控免疫细胞的研究进展

余静¹, 刘可^1,2, 王海燕¹, 严军^1*

1. 陆军军医大学野战外科研究部特殊环境战伤防治研究室,创伤、烧伤与复合伤国家重点实验室, 重庆 400042;
2.西南交通大学生命科学与工程学院, 四川成都 610031

收稿日期:2020-09-14 修回日期:2020-12-09 发布日期:2021-12-03
通讯作者: *13883092250@163.com
基金资助:
国家科技重大专项(2019ZX09301-167);陆军军医大学科技创新能力提升专项军事医学预研项目(2019XYY22)

Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytes

YU Jing¹, LIU Ke^1,2, WANG Hai-yan¹, YAN Jun^1*

1. Department of Special War Wound, State Key Laboratory of Trauma, Burns and Combined Injury, Research Institute of Surgery,Army Medical University, Chongqing 400042;
2. School of Life Science and Engineering, Southwest Jiaotong University,Chengdu 610031, China

Received:2020-09-14 Revised:2020-12-09 Published:2021-12-03
Contact: *13883092250@163.com

摘要/Abstract

摘要： 非甾体抗炎剂(NSAIDs)具有抗感染、抗风湿、止痛、退热和抗凝血作用,广泛应用于炎性反应、发热和疼痛缓解治疗,并与免疫细胞的关系密切。NSAIDs可通过抑制PG负向调控B细胞增殖;改变Th1/Th2失衡及Th17分化导致的免疫紊乱;抑制巨噬细胞分泌TNF-α,控制其他炎性介质的分泌和释放,调控炎性反应进程。其调控机制可能与PGE2-EP2、5-HT、GLP-2和NF-κB-IL-6-STAT3等信号途径有关。因此,深入研究NSAIDs对各类免疫细胞的调控作用及其机制是必要的,将为伤病后机体免疫功能的改善提供新策略。

关键词: 非甾体抗炎剂, 调控, 免疫细胞

Abstract: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely applied in the treatment of inflammation, fever and for pain relief based on its efficacy in anti-inflammatory, anti-rheumatic, analgesic, antipyretic, and anticoagulation. Moreover, the relationship between NSAIDs and immune cells is quite important since. NSAIDs can negatively regulate B cell proliferation via inhibiting prostaglandin (PG), improve the imbalance of Th1/Th2 and immunologic derangement caused by Th17 differentiation, inhibit release of TNF-α by macrophages and decrease the level of tumor necrosis factor (TNF)-α, influence inflammation via controlling other inflammatory cytokines. In addition, the mechanism may be concerned with several signal pathways including PGE2 receptor 2 (PGE2-EP2), 5-hydroxytryptamine(5-HT), glucagon-like peptide-2 (GLP-2) and nuclear factor kappa-B-interleukin-6- signal transducer and activator of transcription 3 (NF-κB-IL-6-STAT3). Thus, it is necessary to further investigate the regulation and mechanism of NSAIDs on various immunocytes, potentially provide a new strategy to optimize immune funtions under trauma and disease.

Key words: non-steroidal anti-inflammatory drugs (NSAIDs), regulation, immunocyte

中图分类号:

余静, 刘可, 王海燕, 严军. 非甾体抗炎剂调控免疫细胞的研究进展[J]. 基础医学与临床, 2021, 41(12): 1833-1837.

YU Jing, LIU Ke, WANG Hai-yan, YAN Jun. Research progress in regulation of non-steroidal anti-inflammatory drugs on immunocytes[J]. Basic & Clinical Medicine, 2021, 41(12): 1833-1837.

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