线粒体移植的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (12): 1838-1842.

线粒体移植的研究进展

王一川, 刘小静^*, 叶峰, 杨雪亮, 陈娜, 吴剑华, 李彦霖

西安交通大学第一附属医院感染科, 陕西西安 710016

收稿日期:2021-03-12 修回日期:2021-07-12 发布日期:2021-12-03
通讯作者: *xiaojing406@163.com
基金资助:
陕西省自然科学基础研究计划(2017JM8083)

Research progress of mitochondrial transplantation

WANG Yi-chuan, LIU Xiao-jing^*, YE Feng, YANG Xue-liang, CHEN Na, WU Jian-hua, LI Yan-lin

Department of Infection, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710016, China

Received:2021-03-12 Revised:2021-07-12 Published:2021-12-03
Contact: *xiaojing406@163.com

摘要/Abstract

摘要： 线粒体提供细胞生命活动的大部分能量,其功能异常可导致多种疾病。基于线粒体能够在细胞间转移的机制,线粒体移植成为治疗线粒体功能障碍的一种创新思路。在动物实验中被证明是一种治疗包括心脏、肝脏、肺和大脑在内的各种组织的线粒体功能障碍的方法。在临床试验中,这项技术有待广泛应用。

关键词: 线粒体移植, 线粒体治疗

Abstract: Mitochondria provides most of the energy to drive cell function, and its dysfunction can lead to a variety of disease. Since mitochondria has been proved to be able to transfer between cells, mitochondrial transplantation has become an innovative idea for the treatment of mitochondrial dysfunction and this technology has been supported by evidences from animal experiments. The transplantation of mitochondrial is potentially applied in the treatment of disease of various tissues including heart, liver, lung and brain.

Key words: mitochondrial transplantation, mitochondrial therapy

中图分类号:

王一川, 刘小静, 叶峰, 杨雪亮, 陈娜, 吴剑华, 李彦霖. 线粒体移植的研究进展[J]. 基础医学与临床, 2021, 41(12): 1838-1842.

WANG Yi-chuan, LIU Xiao-jing, YE Feng, YANG Xue-liang, CHEN Na, WU Jian-hua, LI Yan-lin. Research progress of mitochondrial transplantation[J]. Basic & Clinical Medicine, 2021, 41(12): 1838-1842.

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