Spinophilin在神经系统疾病中的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (10): 1507-1509.

Spinophilin在神经系统疾病中的研究进展

邢靖松^1,2, 克甜甜^1,2, 张琳^1,2, 梁东², 张桐¹, 高尚锋^1,2*

1.徐州医科大学附属医院神经外科, 江苏徐州 221002;
2.徐州医科大学神经系统疾病研究所, 江苏徐州 221002

收稿日期:2020-04-17 修回日期:2020-11-19 发布日期:2021-09-29
通讯作者: *gaoshangfeng@xzhmu.edu.cn
基金资助:
国家自然科学基金面上项目(82072763);江苏省“六大人才高峰”高层次人才项目(2019-SWYY-092);江苏省高等学校大学生创新创业训练计划(201810313044Y)

Research progress of spinophilin in nervous system diseases

XING Jing-song^1,2, KE Tian-tian^1,2, ZHANG Lin^1,2, LIANG Dong², ZHANG Tong¹, GAO Shang-feng^1,2*

1. Department of Neurosurgery, the Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002;
2. Institute of Nervous System Diseases, Xuzhou Medical University, Xuzhou 221002, China

Received:2020-04-17 Revised:2020-11-19 Published:2021-09-29
Contact: *gaoshangfeng@xzhmu.edu.cn

摘要/Abstract

摘要： Spinophilin(SPN)最早作为蛋白磷酸酶PP1的结合蛋白从神经元树突棘中分离出来,故又名PPP1R9B。SPN不仅与PP1结合,而且与包括细胞骨架蛋白、黏附分子等30多个蛋白存在相互作用,参与突触可塑性、神经元迁移、胞内信号传导等生物学过程,并在神经退行性疾病、精神性疾病和神经肿瘤进展中发挥重要作用。因此,了解SPN在上述生理和病理过程中的作用及机制将有助于推进SPN基础研究与临床转化的进展。

关键词: spinophilin, 帕金森病, 抑郁症, 胶质瘤

Abstract: Spinophilin (SPN) was first isolated from the dendritic spines of neurons as a binding protein of protein phosphatase PP1, it is also known as PPP1R9B. SPN can not only bind to PP1, but also interacts with more than 30 proteins, including cytoskeleton proteins and adhesion molecules. SPN participates in biological processes such as synaptic plasticity, neuronal migration, intracellular signal transduction, and plays an important role in the development of neurodegenerative diseases, psychiatric disorders and neuronal tumors. Therefore, understanding the role and mechanism of SPN in the physiological and pathological processes may support is helpful to advance the basic research and clinical transformation.

Key words: spinophilin, Parkinson's disease, depression, glioma

中图分类号:

R651

邢靖松, 克甜甜, 张琳, 梁东, 张桐, 高尚锋. Spinophilin在神经系统疾病中的研究进展[J]. 基础医学与临床, 2021, 41(10): 1507-1509.

XING Jing-song, KE Tian-tian, ZHANG Lin, LIANG Dong, ZHANG Tong, GAO Shang-feng. Research progress of spinophilin in nervous system diseases[J]. Basic & Clinical Medicine, 2021, 41(10): 1507-1509.

参考文献

[1]Allen PB, Ouimet CC, Greengard P. Spinophilin, a novel protein phosphatase 1 binding protein localized to dendritic spines[J]. Proc Natl Acad Sci U S A, 1997,94:9956-9961.
[2]Salek AB, Edler MC, McBride JP, et al. Spinophilin regulates phosphorylation and interactions of the GluN2B subunit of the N-methyl-d-aspartate receptor[J]. J Neurochem,2019,151:185-203.
[3]Sarrouilhe D, di Tommaso A, Métayé T, et al. Spinophilin: from partners to functions[J]. Biochimie, 2006,88:1099-1113.
[4]Ouimet CC, Katona I, Allen P, et al. Cellular and subcellular distribution of spinophilin, a PP1 regulatory protein that bundles F-actin in dendritic spines[J]. J Comp Neurol, 2004,479:374-388.
[5]Horling K, Schlegel G, Schulz S, et al. Hippocampal synaptic connectivity in phenylketonuria[J]. Hum Mol Genet,2015,24:1007-1018.
[6]Dunn HA, Ferguson SS. PDZ protein regulation of G protein-coupled receptor trafficking and signaling pathways[J]. Mol Pharmacol, 2015,88:624-639.
[7]Brocos-Mosquera I, Nuñez Del Moral A, Morentin B, et al. Characterisation of spinophilin immunoreactivity in postmortem human brain homogenates[J]. Prog Neuropsychopharmacol Biol Psychiatry, 2018,81:236-242.
[8]Hiday AC, Edler MC, Salek AB, et al. Mechanisms and consequences of dopamine depletion-induced attenuation of the spinophilin/neurofilament medium interaction[J]. Neural Plast, 2017,2017:4153076. doi:10.1155/2017/4153076.
[9]Verdugo-Sivianes EM, Navas L, Molina-Pinelo S, et al. Coordinated downregulation of Spinophilin and the catalytic subunits of PP1, PPP1CA/B/C, contributes to a worse prognosis in lung cancer[J]. Oncotarget, 2017,8:105196-105210.
[10]Ferrer I, Blanco-Aparicio C, Peregrina S, et al. Spinophilin acts as a tumor suppressor by regulating Rb phosphorylation[J]. Cell Cycle, 2011,10:2751-2762.
[11]Palavicini JP, Wang H, Bianchi E, et al. RanBP9 aggravates synaptic damage in the mouse brain and is inversely correlated to spinophilin levels in Alzheimer's brain synaptosomes[J].Cell Death Dis, 2013,4:e667. doi:10.1038/cddis.2013.183.
[12]Taniguchi K, Yamamoto F, Arai T, et al. Tyrosol reduces amyloid-β oigomer neurotoxicity and alleviates synaptic, oxidative, and cognitive disturbances in Alzheimer's disease model mice[J]. J Alzheimers Dis, 2019,70:937-952.
[13]Mi Z, Abrahamson EE, Ryu AY, et al. Loss of precuneus dendritic spines immunopositive for spinophilin is related to cognitive impairment in early Alzheimer's disease[J]. Neurobiol Aging, 2017,55:159-166.
[14]Akram A, Christoffel D, Rocher AB, et al. Stereologic estimates of total spinophilin-immunoreactive spine number in area 9 and the CA1 field: relationship with the progression of Alzheimer's disease[J]. Neurobiol Aging, 2008,29:1296-1307.
[15]Gao S, Zhang T, Jin L, et al. CAPON is a critical protein in synaptic molecular networks in the prefrontal cortex of mood disorder patients and contributes to depression-like behavior in a mouse model[J]. Cereb Cortex, 2019,29:3752-3765.
[16]Edler MC, Salek AB, Watkins DS, et al. Mechanisms regulating the association of protein phosphatase 1 with Spinophilin and Neurabin[J]. ACS Chem Neurosci, 2018,9:2701-2712.
[17]Wesseling P, Capper D. WHO 2016 Classification of gliomas[J]. Neuropathol Appl Neurobiol, 2018,44:139-150.
[18]Cheerathodi M, Avci NG, Guerrero PA, et al. The cytoskeletal adapter protein Spinophilin regulates invado-podia dynamics and tumor cell invasion in glioblastoma[J]. Mol Cancer Res, 2016,14:1277-1287.