玫瑰痤疮共病的研究进展

基础医学与临床 ›› 2021, Vol. 41 ›› Issue (10): 1502-1506.

玫瑰痤疮共病的研究进展

张翰林, 杨子涵, 王远卓, 郑清月, 唐珂韵, 房柔妤, 孙秋宁^*

中国医学科学院北京协和医学院北京协和医院皮肤科, 北京 100730

收稿日期:2021-03-08 修回日期:2021-06-20 发布日期:2021-09-29
通讯作者: *doctorjenny1@163.com
基金资助:
国家级大学生创新训练计划项目(202010023007)

Recent advances in rosacea comorbidities

ZHANG Han-lin, YANG Zi-han, WANG Yuan-zhuo, ZHENG Qing-yue, TANG Ke-yun, FANG Rou-yu, SUN Qiu-ning^*

Department of Dermatology, Peking Union Medical College Hospital, CAMS & PUMC, Beijing 100730, China

Received:2021-03-08 Revised:2021-06-20 Published:2021-09-29
Contact: *doctorjenny1@163.com

摘要/Abstract

摘要： 玫瑰痤疮是一种好发于面中部的慢性炎性皮肤病,可与多种全身性疾病并发。本文对玫瑰痤疮的多种共病,包括心血管疾病、代谢疾病、消化疾病、肿瘤、神经精神疾病等进行综述,并对玫瑰痤疮的共病问题给出处理建议。若发现患者具有其他疾病的症状、体征或实验室检查、影像学检查结果的异常,则应将其转诊到相应科室就诊。需要进一步研究玫瑰痤疮与其共病的关系,尤其是不同类型的玫瑰痤疮与其共病的关系,以加强玫瑰痤疮患者临床治疗和管理的针对性。

关键词: 玫瑰痤疮, 共病

Abstract: Rosacea is a chronic inflammatory skin disease mainly affecting the middle of the face with a variety of systemic comorbidities. This article reviews comorbidities of rosacea, including cardiovascular diseases, metabolic diseases, digestive diseases, malignancies, and neuropsychiatric diseases, and provides suggestions on how to deal with comorbidities of rosacea. If rosacea patients have symptoms or signs of other diseases, or abnormal results of laboratory examinations or imaging examinations, they should be referred to the corresponding department for further treatment. It is necessary to further investigate the relationship between rosacea and its comorbidities, especially the relationship between different subtypes of rosacea and their comorbidities, to facilitate the treatment and management of rosacea patients.

Key words: rosacea, comorbidities

中图分类号:

R758.73

张翰林, 杨子涵, 王远卓, 郑清月, 唐珂韵, 房柔妤, 孙秋宁. 玫瑰痤疮共病的研究进展[J]. 基础医学与临床, 2021, 41(10): 1502-1506.

ZHANG Han-lin, YANG Zi-han, WANG Yuan-zhuo, ZHENG Qing-yue, TANG Ke-yun, FANG Rou-yu, SUN Qiu-ning. Recent advances in rosacea comorbidities[J]. Basic & Clinical Medicine, 2021, 41(10): 1502-1506.

参考文献

[1]Duman N, Ersoy Evans S, Atakan N. Rosacea and cardiovascular risk factors: a case control study[J]. J Eur Acad Dermatol,2014,28:1165-1169.
[2]Hua TC, Chung PI, Chen YJ, et al. Cardiovascular comorbidities in patients with rosacea: a nationwide case-control study from Taiwan[J]. J Am Acad Dermatol,2015,73:249-254.
[3]Egeberg A, Hansen PR, Gislason GH, et al. Assessment of the risk of cardiovascular disease in patients with rosacea[J]. J Am Acad Dermatol,2016,75:336-339.
[4]Sinikumpu SP, Jokelainen J, Auvinen J, et al. Increased risk of cardiovascular diseases in female rosacea patients: a Nested Case-control Study[J]. Acta Derm-Venereol,2019,99:705-706.
[5]Dosal JR, Rodriguez GL, Pezon CF, et al. Effect of tetracyclines on the development of vascular disease in veterans with acne or rosacea: a retrospective cohort study[J]. J Invest Dermatol,2014,134:2267-2269.
[6]Chang ALS, Raber I, Xu J, et al. Assessment of the genetic basis of rosacea by genome-wide association study[J]. J Invest Dermatol,2015,135:1548-1555.
[7]Akin Belli A, Ozbas Gok S, Akbaba G, et al. The relationship between rosacea and insulin resistance and metabolic syndrome[J]. Eur J Dermatol,2016,26:260-264.
[8]Li S, Cho E, Drucker AM, et al. Obesity and risk for incident rosacea in US women[J]. J Am Acad Dermatol,2017,77:1083-1087.e5.
[9]Son JH, Chung BY, Jung MJ, et al. The risk of rosacea according to chronic diseases and medications: a 5-year retrospective, multi-institutional case-control study[J]. Ann Dermatol,2018,30:676-687.
[10]Karaosmanoglu N, Karaaslan E, Ozdemir Cetinkaya P. Evaluation of serum uric acid levels in patients with rosacea[J]. Arch Dermatol Res,2020,312:447-451.
[11]Egeberg A, Weinstock LB, Thyssen EP, et al. Rosacea and gastrointestinal disorders: a population-based cohort study[J]. Brit J Dermatol,2017,176:100-106.
[12]Wu CY, Chang YT, Juan CK, et al. Risk of inflammatory bowel disease in patients with rosacea: results from a nationwide cohort study in Taiwan[J]. J Am Acad Dermatol,2017,76:911-917.
[13]Sharma VK, Lynn A, Kaminski M, et al. A study of the prevalence of Helicobacter pylori infection and other markers of upper gastrointestinal tract disease in patients with rosacea[J]. Am J Gastroenterol,1998,93:220-222.
[14]Jørgensen AR, Egeberg A, Gideonsson R, et al. Rosacea is associated with Helicobacter pylori: a systematic review and meta-analysis[J]. J Eur Acad Dermatol,2017,31:2010-2015.
[15]Tan J, Berg M. Rosacea: current state of epidemiology[J]. J Am Acad Dermatol,2013,69:S27-S35.
[16]Li WQ, Zhang M, Danby FW, et al. Personal history of rosacea and risk of incident cancer among women in the US[J]. Brit J Cancer,2015,113:520-523.
[17]Egeberg A, Hansen PR, Gislason GH, et al. Association of rosacea with risk for glioma in a Danish nationwide cohort study[J]. JAMA Dermatol,2016,152:541-545.
[18]Egeberg A, Fowler JF, Gislason GH, et al. Rosacea and risk of cancer in Denmark[J]. Cancer Epidemiol,2017,47:76-80.
[19]Chang TH, Ho HJ, Chang YT, et al. Is rosacea a risk factor for cancer: a population-based cohort study in Taiwan[J]. Dermatol Sin,2020,38:15. doi: 10.4103/ds.ds_30_19.
[20]Egeberg A, Hansen PR, Gislason GH, et al. Exploring the association between rosacea and Parkinson disease: a Danish nationwide cohort study[J]. JAMA Neurol,2016,73:529-534.
[21]Egeberg A, Hansen PR, Gislason GH, et al. Patients with rosacea have increased risk of dementia[J]. Ann Neurol,2016,79:921-928.
[22]Tan SG, Cunliffe WJ. Rosacea and migraine[J]. BMJ-Brit Med J,1976,1:21. doi:10.1136/bmj.1.6000.21.
[23]Christensen CE, Andersen FS, Wienholtz N, et al. The relationship between migraine and rosacea: systematic review and meta-analysis[J]. Cephalalgia,2018,38:1387-1398.
[24]Wu Y, Fu C, Zhang W, et al. The dermatology life quality index (DLQI) and the hospital anxiety and depression (HADS) in Chinese rosacea patients[J]. Psychol Health Med,2018,23:369-374.
[25]Hung CT, Chiang CP, Chung CH, et al. Risk of psychiatric disorders in rosacea: a nationwide, population-based, cohort study in Taiwan[J]. J Dermatol,2019,46:110-116.