成瘤性相关蛋白的研究进展

基础医学与临床 ›› 2020, Vol. 40 ›› Issue (12): 1716-1720.

成瘤性相关蛋白的研究进展

敖慧娟^1,3, 石嘉琛^1,3, 王家敏^1,2, 阿依木古丽·阿不都热依木^1,3, 乔自林^1,2, 杨琨^1,3*

1.西北民族大学生物医学研究中心甘肃省动物细胞技术创新中心;
2.西北民族大学生物医学研究中心生物工程与技术国家民委重点实验室,甘肃兰州 730030;
3.西北民族大学生命科学与工程学院, 甘肃兰州 730030

收稿日期:2020-06-09 修回日期:2020-08-21 出版日期:2020-12-05 发布日期:2020-11-30
通讯作者: ^* 119260378@qq.com
基金资助:
中央高校基本科研业务费专项资金(31920190024,31920190004);西北民族大学中央高校基本科研业务费专项资金(Yxm2020122);教育部动物医学生物工程创新团队(IRT-17R88)

Research progress of tumorigenicity-related proteins

AO Hui-juan^1,3, SHI Jia-chen^1,3, WANG Jia-min^1,2, Ayimuguli ABUDUREYIMU^1,3, QIAO Zi-lin^1,2, YANG Kun^1,3*

1. Gansu Technology Innovation Center of Animal Cell;
2. Key Laboratory of Biotechnology and Bioengineering of State Ethnic Affairs Commission, Biomedical Research Center, Northwest Minzu University, Lanzhou 730030;
3. College of Life Science and Engineering, Northwest Minzu University, Lanzhou 730030,China

Received:2020-06-09 Revised:2020-08-21 Online:2020-12-05 Published:2020-11-30
Contact: ^* 119260378@qq.com

摘要/Abstract

摘要： 肿瘤的发生发展包括肿瘤细胞的体内成瘤性、异种移植肿瘤的生长、血管生成、肿瘤迁移侵袭及转移等过程,而成瘤性相关蛋白在此过程中发挥着重要的调控作用。研究成瘤性相关蛋白对发现肿瘤治疗的新靶点、阻断肿瘤发生发展等具有重要意义。本文综述了成瘤性相关蛋白对细胞成瘤性的影响、蛋白相互作用对肿瘤迁移侵袭的影响、成瘤性相关蛋白在体外细胞迁移侵袭中的作用及其与肿瘤转移之间的关系,以期为揭示成瘤性相关蛋白在肿瘤发展中的调控机制提供参考。

关键词: 肿瘤细胞, 成瘤性, 蛋白

Abstract: The occurrence and development of tumors include the tumorigenicity of tumor cells in vivo, the growth of xenograft tumors, angiogenesis, tumor migration, invasion and metastasis. Tumorigenicity-related proteins play an important regulatory role during these processes. Research of tumorigenicity-related proteins is of great significance for identifing new targets for tumor treatment and blocking tumor occurrence and development. We reviewed the effects of tumorigenicity-related proteins on cell tumorigenesis, the consequence of protein interactions on tumor migration and invasion, the effects of tumorigenicity-related proteins on cell migration and invasion in vitro, and their relationship with tumor metastasis. This review provides rich information on the regulatory mechanism of tumorigenicity-related proteins in tumor development.

Key words: tumor cells, tumorigenicity, protein

中图分类号:

敖慧娟, 石嘉琛, 王家敏, 阿依木古丽·阿不都热依木, 乔自林, 杨琨. 成瘤性相关蛋白的研究进展[J]. 基础医学与临床, 2020, 40(12): 1716-1720.

AO Hui-juan, SHI Jia-chen, WANG Jia-min, Ayimuguli ABUDUREYIMU, QIAO Zi-lin, YANG Kun. Research progress of tumorigenicity-related proteins[J]. Basic & Clinical Medicine, 2020, 40(12): 1716-1720.

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