基础医学与临床 ›› 2017, Vol. 37 ›› Issue (9): 1247-1250.

• 研究论文 • 上一篇    下一篇

多种脂源性细胞因子与2型糖尿病患者胰岛素抵抗相关

王丽萍,宋斌,戴燕,陈晖,张真稳,闫彩凤,潘云龙   

  1. 江苏省苏北人民医院
  • 收稿日期:2017-05-09 修回日期:2017-06-22 出版日期:2017-09-05 发布日期:2017-08-28
  • 通讯作者: 潘云龙 E-mail:njphpyl@163.com
  • 基金资助:
    扬州市科技局项目;江苏省苏北人民医院院基金

Multiple lipid derived cytokines are associated with insulin resistance of patients with type 2 diabetes

  • Received:2017-05-09 Revised:2017-06-22 Online:2017-09-05 Published:2017-08-28
  • Supported by:
    Yangzhou city technology bureau project;Northern jiangsu people's hospital of funds

摘要: 目的 探讨T2DM患者多种脂源性细胞因子与胰岛素抵抗作用关系。方法 选择T2DM患者60例,根据BMI水平分为obesity组、Non-obesity组及正常对照组各20人,检测血清空腹胰岛素(FINs)、空腹血糖(FPG)、血浆脂质(TG、TC、LDL、HDL)、脂联素(APN)、C1q/TNF相关蛋白3(CTRP3)、瘦素(Leptin)及肿瘤坏死因子(TNF-a)等指标,根据HOMA公式,计算HOMA-AR并分析各指标之间相关性。结果 1).与正常对照组比较,T2DM组血清APN和CTRP3水平明显降低,Leptin和TNF-a水平升高;与Non-obesity组比较,Obesity组APN和CTRP3的水平明显降低(P<0.05或P<0.01),Leptin水平升高(P<0.05);2).相关分析发现,APN浓度与Age、BMI、FPG、TC、TG、LDL、FINs和HOMA-IR呈负相关(p<0.05);CTRP3与FPG、FINs和HOMA-AR呈负相关(p<0.05),与TG呈正相关(p<0.05);Leptin与FPG呈负相关(p<0.05);TNF-a与FPG呈正相关(p<0.05)。结论:2 型糖尿病患者血清中低 APN 、CTRP3和高Leptin水平与肥胖、HOMA-IR密切相关可能是的发病因子,其中FPG和TG作为独立因子,可作为评价胰岛素抵抗程度的新的敏感指标。

关键词: 关键词:Leptin、TNF-a、APN、CTRP3、2型糖尿病、胰岛素抵抗

Abstract: Objective To explore the relation of fat cells factor and insulin resistance in type 2 diabetes. Method We selected 60 patients divided into obesity group, Non-obese group and Normal control group. To detect the FINs, FPG, TG, TC, LDL,HDL,APN,CTRP3,Leptin and TNF-a, according to the formula of HOMA ,to analyze the correlation between indicators. Results 1). Compared with Normal control group, DM group significantly lower serum APN, CTRP3 level, compared with Non-obesity group, obesity group APN, CTRP3 level significantly decreased(p<0.05 or p<0.01). The Leptin levels elevated (p<0.05). 2). The analysis results found that: APN concentration and Age, BMI, FPG, TG, TC, LDL, FINs, HOMA-IR has significant negative correlation; CTRP3 and FPG, FINs, HOMA-negative correlation IR(p<0.05), TG were positively correlated (p<0.05); TNF-a and FPG and positively correlated (p< 0.05).Conclusion:T2DM patients serum APN, CTRP3 and high Leptin levels are closely associated with obesity, HOMA-IR, FPG and TG as an independent factor can be used as a new sensitive index of evaluating the degree of insulin resistance.

Key words: Keywords: Leptin, TNF - a, APN, CTRP3, type 2 diabetes and insulin resistance

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