基础医学与临床 ›› 2016, Vol. 36 ›› Issue (10): 1446-1449.
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郑丽萍1,牛培广2,史道华2
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摘要: 氨基酸是合成蛋白质的底物,也可作为信号分子激活哺乳动物雷帕霉素靶蛋白复合体1 (mTORC1)。氨基酸调控mTORC1活性的关键步骤是将mTORC1定位于溶酶体表面,RagGTPase、Ragulator、v-ATPase和SLC38A9等溶酶体相关蛋白及GATOR、Sestrins等胞质蛋白在其中发挥重要的作用。
关键词: mTORC1通路, Rag GTPase, Ragulator, v-ATPase, SLC38A9, GATOR, Sestrins
Abstract: Amino acids not only are materials for protein synthesis,but also are signaling molecules that activate Mammalian target of Rapamycin complex 1 (mTORC1).mTORC1 translocation to the lysosomal surface is the key step to regulation of mTORC1 activity by amino acids. Lysosome associated proteins including RagGTPase,Ragulator,v-ATPase and SLC38A9,and some cytoplasmic proteins,such as GATOR,Sestrins,have an important role in regulation of mTORC1 translocation to the lysosomal surface.
Key words: mTORC1 pathway, Rag GTPase, Ragulator, v-ATPase, SLC38A9, GATOR, Sestrins
中图分类号:
R34
郑丽萍 牛培广 史道华. 氨基酸调节mTORC1信号通路的研究进展[J]. 基础医学与临床, 2016, 36(10): 1446-1449.
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