基础医学与临床 ›› 2016, Vol. 36 ›› Issue (10): 1446-1449.

• 短篇综述 • 上一篇    下一篇

氨基酸调节mTORC1信号通路的研究进展

郑丽萍1,牛培广2,史道华2   

  1. 1. 福建省妇幼保健院 福建医科大学教学医院
    2. 福建省妇幼保健院
  • 收稿日期:2015-12-03 修回日期:2016-01-26 出版日期:2016-10-05 发布日期:2016-09-27
  • 通讯作者: 史道华 E-mail:shidh@yeah.net
  • 基金资助:
    福建省自然科学基金;福建省自然科学基金

Research progress in regulation of mTORC1 signaling pathway by amino acids

  • Received:2015-12-03 Revised:2016-01-26 Online:2016-10-05 Published:2016-09-27

摘要: 氨基酸是合成蛋白质的底物,也可作为信号分子激活哺乳动物雷帕霉素靶蛋白复合体1 (mTORC1)。氨基酸调控mTORC1活性的关键步骤是将mTORC1定位于溶酶体表面,RagGTPase、Ragulator、v-ATPase和SLC38A9等溶酶体相关蛋白及GATOR、Sestrins等胞质蛋白在其中发挥重要的作用。

关键词: mTORC1通路, Rag GTPase, Ragulator, v-ATPase, SLC38A9, GATOR, Sestrins

Abstract: Amino acids not only are materials for protein synthesis,but also are signaling molecules that activate Mammalian target of Rapamycin complex 1 (mTORC1).mTORC1 translocation to the lysosomal surface is the key step to regulation of mTORC1 activity by amino acids. Lysosome associated proteins including RagGTPase,Ragulator,v-ATPase and SLC38A9,and some cytoplasmic proteins,such as GATOR,Sestrins,have an important role in regulation of mTORC1 translocation to the lysosomal surface.

Key words: mTORC1 pathway, Rag GTPase, Ragulator, v-ATPase, SLC38A9, GATOR, Sestrins

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