基础医学与临床 ›› 2014, Vol. 34 ›› Issue (8): 1138-1141.

• 短篇综述 • 上一篇    下一篇

细胞源性微粒在急性肺损伤中双重作用的研究进展

黄竹萍,莫中成,王德明   

  1. 南华大学附属第二医院
  • 收稿日期:2013-11-18 修回日期:2013-12-20 出版日期:2014-08-05 发布日期:2014-07-15
  • 通讯作者: 王德明 E-mail:wdm1998@163.com
  • 基金资助:
    LXRs抑炎新机制:miR-33/MARK1/TTP通路介导的炎症因子mRNA降解

Advancement of the dual roles of cell microparticles in acute lung injury

  • Received:2013-11-18 Revised:2013-12-20 Online:2014-08-05 Published:2014-07-15

摘要: 微粒是细胞衍生的微小囊泡,携带有母细胞来源的多种物质,能与靶细胞发挥相互作用。微粒对急性肺损伤(ALI)的多种病理生理过程具有双重调节作用,能够通过多种机制影响炎性反应、凝血功能、血管通透性、内皮细胞凋亡等。因此,微粒对ALI的发生发展具有重要意义。

关键词: 微粒, 急性肺损伤, 炎性反应

Abstract: Microparticles, a kinds of small vesicles derived from the mother cells with a variety of contents, have been reported to involve in a variety of pathophysiological processes. The variety of contents which microparticles contain also can affect the coagulation function and inflammation.. And microparticles can also influence the apoptosis of endothelial cells and the function of vascular barrier through various mechanisms. Therefore, microparticles have great significance on the occurrence and progress of acute lung injury.

Key words: microparticles, acute lung injury, inflammation

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