基础医学与临床 ›› 2014, Vol. 34 ›› Issue (6): 866-869.
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武雪亮,王立坤,薛军,贾光辉,屈明,赵秀芳
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摘要: RUNX3是人runt相关转录因子家族中的一员,它参与细胞的增值、生长与凋亡的调控。RUNX3表达的异常如杂合缺失、高甲基化与多种恶性肿瘤的发生、发展以及预后有明显的关系,尤其在胃癌、结直肠癌及肝癌的发生、发展中发挥着重要作用。
关键词: 【关键词】RUNX3抑癌基因, TGF-β, Wnt, 消化系肿瘤
Abstract: RUNX3(hunan Runt-related transcription factor 3) playing important roles in regulation on cell proliferation,cell proliferation and cell apoptosis is a member of the Runt-related transcription factor family.The abnormal expression of RUNX3,such as heterozygous deficiency,hyper-methylation,has significant relationship to the occurrence,development,and prognosis of malignant tumor,and especially plays important roles in the occurrence and development of gastric cancer,colorectal cancer, and liver cancer.
武雪亮 王立坤 薛军 贾光辉 屈明 赵秀芳. RUNX3参与抑制消化系肿瘤的进展 [J]. 基础医学与临床, 2014, 34(6): 866-869.
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