基础医学与临床 ›› 2013, Vol. 33 ›› Issue (10): 1352-1355.
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吴小妹1,曾敏1,谭利明1,黄志凌2,朱灿1,刘飞1
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摘要: 腺苷具有抗惊厥作用,增加癫痫病灶中腺苷水平的治疗即腺苷增强治疗(AATs)已成为癫痫治疗研究的热点。系统药物AATs有抗痫效应但伴有广泛不良反应。局部AATs通过基因技术与干细胞技术产生的大脑移植物能释放治疗量腺苷发挥强大的抗癫痫作用,但其安全性及临床可行性还有待进一步研究。
关键词: 癫痫, 腺苷, 腺苷激酶, 细胞治疗, 基因治疗
Abstract: Adenosine is an endogenous anticonvulsant transmitter in the brain. Recent researches suggest increasing site- and event-specific adenosine (adenosine augmentation therapies AATs) may become a novel therapy for epilepsy. Systemic pharmacological AATs are effective in seizure suppression, however accompanied by wide-spread side-effects. Therapeutic tools to achieve focal AAT, stem cells have been engineered to release therapeutic amounts of adenosine using RNA interference or gene targeting technology, providing robust protection from spontaneous seizures, but determining the most effective and compatible strategies with clinical applications needs more future research.
Key words: epilepsy, adenosine , adenosine kinase , cell therapy , gene therapy
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R742.1
吴小妹 曾敏 谭利明 黄志凌 朱灿 刘飞. 腺苷增强治疗(AATs)在癫痫治疗的研究进展[J]. 基础医学与临床, 2013, 33(10): 1352-1355.
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http://journal11.magtechjournal.com/Jwk_jcyxylc/CN/Y2013/V33/I10/1352