Expression of KIF23 in rectal cancer tissues is correlated with prognosis

doi:10.16352/j.issn.1001-6325.2025.08.1054

Abstract

Abstract: Objective To investigate the expression of kinesin family member 23 (KIF23) in rectal cancer and its association with prognosis. Methods This study included 90 patients with rectal cancer who underwent surgical treatment at the First Central Hospital of Baoding from May 2017 to October 2019. Immunohistochemical staining was used to detect KIF23 expression, and the results were analyzed in combination with clinical and pathological data. Survival analysis was conducted using Kaplan-Meier methods and Cox proportional hazards models to assess the association between KIF23 expression and patient prognosis. Results Compared with adjacent non-tumor tissues, the expression level of KIF23 protein was significantly higher in rectal cancer tissues. Positive expression of KIF23 was significantly correlated with TNM stage, lymph node metastasis and distant metastasis in rectal cancer patients (P＜0.05). Kaplan-Meier analysis revealed that individuals expressing high levels of KIF23 experienced notably diminished disease-free survival (DFS) and overall survival (OS) relative to those with low KIF23 expression(P＜0.05). Cox regression analysis revealed that advanced TNM stage, lymph node metastasis, distant metastasis, and elevated KIF23 expression served as an independent predictor of adverse outcomes in patients with rectal cancer (P＜0.05). Conclusions The expression level of KIF23 is closely related to the prognosis of rectal cancer.

Key words: kinesin family member 23, rectal cancer, prognosis

CLC Number:

WU Haifeng, LI Xiaolong, LI Fang, CHEN Xiaohua, SONG Rui, HAN Xue. Expression of KIF23 in rectal cancer tissues is correlated with prognosis[J]. Basic & Clinical Medicine, 2025, 45(8): 1054-1058.

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