Abstract: Objective To study the performance of serum amyloid A (SAA), procalcitonin (PCT) and hypersensitive C-reactive protein (hs-CRP) in predicting and evaluating therapeutic efficacy of neonatal septicemia. Methods Totally 63 neonates with clinical diagnosis of septicemia and 50 healthy neonates as control from January 2021 to April 2024 were enrolled this study. The clinical features and the Results of SAA, PCT and hs-CRP were compared between the two groups; The Results of SAA, PCT and hs-CRP of neonates suffering from septicemia with different therapeutic outcomes were compared. Results There was no significant difference in clinical features(age, birth weight, mode of delivery, etc.) between the two groups, and the positive rate of blood culture in neonates with septicemia was only 12.7%, gram-positive cocci were the main pathogens; The level of SAA, PCT and hs-CRP in sepsis group was significantly higher than those in control group(P＜0.01);The area under the receiver operating characteristic(ROC) curve(AUC) of the three indexes was higher than 0.7, and the AUC of the combined detectionwas 0.9, the sensitivity was 90.55%; The Results of the three indexes were significantly decreased in effective group after treatment(P＜0.01), and the AUC of the joint detection in evaluating therapeutic efficacy was 0.77, the sensitivity and specificity were 65.36% and 82.45% respectively. Conclusions A combined detection of SAA, PCT and hs-CRP shows high value in diagnosis and prognosis prediction of neonatal septicemia.

Key words: serum amyloid A, procalcitonin, hypersensitive C-reactive protein, septicemia, neonates