Progress of research on the mechanism of GPSM2 in tumor development

doi:10.16352/j.issn.1001-6325.2024.10.1447

Abstract

Abstract: G-protein signaling modulator 2 (GPSM2) is a negative regulator of G protein coupled receptor signaling pathway, which plays an important role in cell growth. In recent years, it has been found that GPSM2 is abnormally expressed in a variety of malignant tumors and is related to many clinical symptoms of tumors. Based on the structure and function of GPSM2, this paper discusses its role and mechanism in tumor development, so as to identify new targets for tumor diagnosis and treatment.

Key words: G-protein signaling modulator 2(GPSM2), tumor, mitosis

CLC Number:

References

[1]Mattiuzzi C, Lippi G. Current cancer epidemiology[J]. J Epidemiol Glob Health, 2019,9:217-222.
[2]Zhu J, Wen W, Zheng Z, et al. Lgn/minsc and lgn/numa complex structures suggest distinct functions in asymmetric cell division for the par3/minsc/lgn and gαi/lgn/numa pathways[J]. Mol Cell, 2011,43:418-431.
[3]McCudden CR, Willard FS, Kimple RJ, et al. G alpha selectivity and inhibitor function of the multiple goloco motif protein gpsm2/lgn[J]. Biochim Biophys Acta, 2005,1745:254-264.
[4]Rondard P, Iiri T, Srinivasan S, et al. Mutant g protein alpha subunit activated by gbeta gamma: a model for receptor activation?[J]. Proc Natl Acad Sci U S A, 2001,98:6150-6155.
[5]Yang D, Ji F, Li Y, et al. Gpsm2 serves as an independent prognostic biomarker for liver cancer survival[J]. Technol Cancer Res Treat, 2020,19:1533033820945817.doi:10.1177/1533033820945817.
[6]He XQ, Zhang YF, Yu JJ, et al. High expression of G-protein signaling modulator 2 in hepatocellular carcinoma facilitates tumor growth and metastasis by activating the pi3k/akt signaling pathway[J]. Tumour Biol, 2017,39:1010428317695971.doi: 10.1177/1010428317695971.
[7]Zhou X, Dang S, Jiang H, et al. Identification of G-protein signaling modulator 2 as a diagnostic and prognostic biomarker of pancreatic adenocarcinoma: an exploration of its regulatory mechanisms[J]. J Gastrointest Oncol, 2021,12:1164-1179.
[8]Fukukawa C, Ueda K, Nishidate T, et al. Critical roles of LGN/GPSM2 phosphorylation by PBK/TOPK in cell division of breast cancer cells[J]. Genes Chromosomes Cancer, 2010,49:861-872.
[9]Gadwal A, Purohit P, Khokhar M, et al. In silico analysis of differentially expressed-aberrantly methylated genes in breast cancer for prognostic and therapeutic targets[J]. Clin Exp Med, 2023,23:3847-3866.
[10]Dang HH, Ta HDK, Nguyen TTT, et al. Identifying gpsm family members as potential biomarkers in breast cancer: a comprehensive bioinformatics analysis[J]. Biomedicines, 2021,9:1144.doi. 10.3390/biomedicines9091144.
[11]Hu LM, Ou XH, Shi SY. A comprehensive analysis of G-protein-signaling modulator 2 as a prognostic and diagnostic marker for pan-cancer[J]. Front Genet, 2022,13:984714.doi: 10.3389/fgene.2022.984714.
[12]Deng M, Liu B, Zhang Z, et al. Loss of G-protein-signaling modulator 2 accelerates proliferation of lung adenocarcinoma via EGFR signaling pathway[J]. Int J of Biochem Cell Biol, 2020,122:105716.doi: 10.1016/j.biocel.2020.105716.
[13]Chen X, Ma J, Wang X, et al. CCNB1 and AURKA are critical genes for prostate cancer progression and castration-resistant prostate cancer resistant to vinblastine[J]. Front Endocrinol, 2022,13:1106175.doi: 10.3389/fendo.2022.1106175.
[14]Deng M, Liu B, Zhang Z, et al. Knockdown of G-protein-signaling modulator 2 promotes metastasis of non-small-cell lung cancer by inducing the expression of Snail[J]. Cancer Sci, 2020,111:3210-3221.
[15]杨铠菲, 朱静格, 张洋洋, 等. 索拉菲尼诱导的细胞凋亡和自噬对hela细胞耐药性的影响[J]. 基础医学与临床, 2024,44:467-473.
[16]郑伟,张建新,谭克,等.下调G蛋白信号调控因子2表达对胰腺癌细胞化疗敏感性的影响[J].中国普通外科杂志,2018,27:321-327.
[17]Zhang Z, Li Z, Deng M, et al. Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer[J]. Oncol Rep, 2020,43:965-974.
[18]Deng M, Zhang Z, Liu B, et al. Localization of GPSM2 in the nucleus of invasive breast cancer cells indicates a poor prognosis[J]. Front Oncol, 2020,10:227.doi: 10.3389/fonc.2020.00227.
[19]张继方,吕庆杰.浆液性卵巢癌中GPSM2的表达与化疗耐药及预后的相关性[J].临床与实验病理学杂志,2020,36:1307-1312.
[20]Han MA, Maisch P, Jung JH, et al. Intravesical gemcitabine for non-muscle invasive bladder cancer[J].Cochrane Database Syst Rev, 2021,6:CD009294.doi: 10.1002/14651858.CD009294.pub3.
[21]Krey JF, Chatterjee P, Halford J, et al. Control of stereocilia length during development of hair bundles[J]. PLoS Biology, 2023,21:e3001964. doi:10.1371/journal.pbio.3001964.
[22]De Francesco EM, Sotgia F, Clarke RB, et al. G protein-coupled receptors at the crossroad between physiologic and pathologic angiogenesis: old paradigms and emerging concepts[J]. Int J Mol Sci, 2017,18:2713.doi: 10.3390/ijms18122713.
[23]Zhou PJ, Wang X, An N, et al. Loss of Par3 promotes prostatic tumorigenesis by enhancing cell growth and changing cell division modes[J]. Oncogene, 2019,38:2192-2205.