CALCOCO1 in the progression of malignant tumors

doi:10.16352/j.issn.1001-6325.2023.11.1733

Abstract

Abstract: Calcium binding and coiled-coil domain 1 (CALCOCO1) is an autophagy regulatory protein being discovered in recent years, which plays an important role in selective autophagy process. The gene coding for autophagy is located at 12q13.13, and its coding protein is CALCOCO1 protein. Which functions by binding to ATG8 family proteins, it anchors to the endoplasmic reticulum and the Golgi apparatus and thus initiate the autophagy of endoplasmic reticulum and Golgi aparatus, and thereby participating in selective autophagy and early stages of autophagosome formation. When the mTOR pathway is activated, mTOR regulates the expression of CALCOCO1 through the autophagy-dependent pathway. CALCOCO1 plays a role in the occurrence and metastasis, and so is a potential target for chemotherapy of malignant tumors.

Key words: autophagy, calcium binding and coiled-coil domain 1 (CALCOCO1), autophagy-related protein 8 family (ATG8), mammalian target of rapamycin (mTOR), tumor

CLC Number:

JIA Nan, WANG Zhilian. CALCOCO1 in the progression of malignant tumors[J]. Basic & Clinical Medicine, 2023, 43(11): 1733-1737.

References 25

[1]	Stefely JA, Zhang Y, Freiberger EC, et al. Mass spectrometry proteomics reveals a function for mammalian CALCOCO1 in MTOR-regulated selective autophagy[J]. Autophagy,2020,16:2219-2237.
[2]	Hirose S, Waku T, Tani M, et al. NRF3 activates mTORC1 arginine-dependently for cancer cell viability[J]. iScience, 2023,26:106045. Published 2023 Jan 25. doi:10.1016/j.isci.2023.106045.
[3]	Ma L, Zhang R, Li D, et al. Fluoride regulates chondrocyte proliferation and autophagy via PI3K/AKT/mTOR signaling pathway[J]. Chem Biol Interact, 2021,349:109659.doi:.
[4]	Park HS, Song JW, Park JH, et al. TXNIP/VDUP1 attenuates steatohepatitis via autophagy and fatty acid oxidation[J]. Autophagy, 2021,17:2549-2564.
[5]	Nthiga TM, Kumar Shrestha B, Sjøttem E, et al. CALCOCO1 acts with VAMP-associated proteins to med-iate ER-phagy[J]. EMBO J, 2020,39:e103649.doi:10.15252/embj.2019103649.
[6]	Nthiga TM, Shrestha BK, Lamark T, et al. CALCOCO1 is a soluble reticulophagy receptor[J]. Autophagy, 2020;16:1729-1731.
[7]	Jatana N, Ascher DB, Pires DEV, et al. Human LC3 and GABARAP subfamily members achieve functional specificity via specific structural modulations[J]. Autophagy, 2020,16:239-255.
[8]	Huber J, Obata M, Gruber J, et al. An atypical LIR motif within UBA5 (ubiquitin like modifier activating enzyme 5) interacts with GABARAP proteins and mediates membrane localization of UBA5[J]. Autophagy, 2020,16:256-270.
[9]	Nguyen TN, Padman BS, Zellner S, et al. ATG4 family proteins drive phagophore growth independently of the LC3/GABARAP lipidation system[J]. Mol Cell, 2021,81:2013-2030.
[10]	Mizushima N. The ATG conjugation systems in autophagy[J]. Curr Opin Cell Biol, 2020,63:1-10.
[11]	Khosrowabadi E, Rivinoja A, Risteli M, et al. SLC4A2 anion exchanger promotes tumour cell malignancy via enhancing net acid efflux across golgi membranes[J]. Cell Mol Life Sci, 2021,78:6283-6304.
[12]	Gohel R, Rahman A, Lõrincz P, et al. Selective auto-phagy and Golgi quality control in <i>Drosophila</i>[J]. Autophagy, 2022,18:2508-2509.
[13]	Rahman A, Lõrincz P, Gohel R, et al. GMAP is an Atg8a-interacting protein that regulates Golgi turnover in Drosophila[J]. Cell Rep, 2022,39:110903. doi:10.1016/j.celrep.2022.110903.
[14]	Haukedal H, Corsi GI, Gadekar VP, et al. Golgi fragmentation-One of the earliest organelle phenotypes in Alzheimer's disease neurons[J]. Front Neurosci, 2023,17:1120086. doi:10.3389/fnins.2023.1120086.
[15]	Yamamoto A. Go for the Golgi: eating selectively with Calcoco1[J]. J Cell Biol, 2021,220. doi:10.1083/jcb.202105005.
[16]	Navarro AP, Cheeseman IM. Identification of a Golgi-localized peptide reveals a minimal Golgi-targeting motif[J]. Mol Biol Cell, 2022,33:ar110. doi:10.1091/mbc.E22-03-0091.
[17]	Nthiga TM, Kumar Shrestha B, Lamark T, et al. The soluble reticulophagy receptor CALCOCO1 is also a Golgiphagy receptor[J]. Autophagy, 2021,17:2051-2052.
[18]	Nthiga TM, Shrestha BK, Bruun JA, et al. Regulation of Golgi turnover by CALCOCO1-mediated selective autophagy[J]. J Cell Biol, 2021;220:e202006128. doi:10.1083/jcb.202006128.
[19]	Liu Y, Zhao R, Fang S, et al. Abemaciclib sensitizes HPV-negative cervical cancer to chemotherapy via specifically suppressing CDK4/6-Rb-E2F and mTOR pathways[J]. Fundam Clin Pharmacol, 2021,35:156-164.
[20]	Segura S, Stolnicu S, Boros M, et al. mTOR pathway activation assessed by immunohistochemistry in cervical biopsies of HPV-associated endocervical adenocarcinomas (HPVA): correlation with silva invasion patterns[J]. Appl Immunohistochem Mol Morphol,2021,29:527-533.
[21]	Brown H, Chung M, Üffing A, et al. Structure-based design of stapled peptides that bind GABARAP and inhibit autophagy[J]. J Am Chem Soc, 2022,144:14687-14697.
[22]	Gray JP, Uddin MN, Chaudhari R, et al. Directed evolution of cyclic peptides for inhibition of autophagy[J]. Chem Sci, 2021,12:3526-3543.
[23]	Ma R, Zhang Z, Xu J, et al. Poricoic acid A induces apoptosis and autophagy in ovarian cancer via modulating the mTOR/p70s6k signaling axis[J]. Braz J Med Biol Res, 2021,54:e11183. doi:10.1590/1414-431X2021e11183.
[24]	Muranen TA, Greco D, Fagerholm R, et al. Breast tumors from CHEK2 1100delC-mutation carriers: genomic landscape and clinical implications[J]. Breast Cancer Res, 2011,13. doi:10.1186/bcr3015.
[25]	Zhang L, He A, Chen B, et al. A HOTAIR regulatory element modulates glioma cell sensitivity to temozolomide through long-range regulation of multiple target genes[J]. Genome Res, 2020,30:155-163.