Correlations of MGMT promoter methylation and IDH1 mutations with the clinical prognosis of malignant glioma patients

Abstract

Abstract: Objective To analyze retrospectively the IDH1 mutation and MGMT promoter methylation of malignant glioma patients and to identify potential relation to clinical situation. Methods Twenty-five patients with glioma who were received treatment from October 2017 to October 2019 were selected; the survival rate was calculated by Kaplan-Meier method and analyzed by Log-Rank test. Results Univariate analysis showed that negative status of MGMT gene promoter methylation(χ²=4.22,P＜0.05) was an important factor affecting the survival rates of patients, and patients with both negative status of MGMT gene promoter methylation and mutation of IDH1 had a significantly prolonged survival(P＜0.05). Conclusions IDH mutation and MGMT promoter methylation status are significantly related to the prognosis of malignant glioma patients.

Key words: glioma, MGMT, IDH1, mutation, prognosis

CLC Number:

R739.41

ZHANG Ning, MA Hui-hui, WANG Fan, LIANG Wei, WANG Yi-chun, WU Bing-shan, LI Qing-xin. Correlations of MGMT promoter methylation and IDH1 mutations with the clinical prognosis of malignant glioma patients[J]. Basic & Clinical Medicine, 2021, 41(10): 1476-1480.

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