Advances in adeno-associated virus mediated gene therapy in tumors

Abstract

Abstract: Adeno-associated virus (AAV) is a human parvovirus with defects and no disease.AAV vector, as an ideal carrier for the transduction of target genes, has certain advantages in long-term gene correction and gene therapy by transferring foreign bases into cells by using the virus's capacity to infect cells.Due to its advantages of extensive host, strong safety and continuous expression of foreign genes, AAV has been used in gene therapy for a variety of tumor.

Key words: AAV, vectors, gene therapy, tumor

CLC Number:

YANG Xiao-juan, LI Zhen-hao, GOU Yuan-feng, HUO Xia-qin, PEI Ya-ping, LI Na, LIU Hui-ling. Advances in adeno-associated virus mediated gene therapy in tumors[J]. Basic & Clinical Medicine, 2021, 41(4): 573-577.

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