Progress in research on mitophagy and pulmonary diseases

Abstract

Abstract: Mitophagy is one of the important forms of selective autophagy, which affects the occurrence and development of lung diseases by regulating the quality of mitochondria in vivo. Mitophagy has different functions in different lung diseases. In idiopathic pulmonary fibrosis and acute lung injury, excessive or low levels of mitophagy can aggravate the diseases; while in pulmonary hypertension, excessive mitophagy levels play the adverse effect in the progress of the disease. Additionally, in chronic obstructive pulmonary disease, mitophagy can regulate cell necrosis and control cellular inflammation. Therefore, it is important to understand the mechanism of mitophagy to prevent and treat lung diseases.

Key words: mitochondrial dysfunction, mitophagy, lung disease

CLC Number:

R364

TAN Shi-Yi, CHEN Shi. Progress in research on mitophagy and pulmonary diseases[J]. Basic & Clinical Medicine, 2020, 40(6): 842-846.

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