Progress in the study of mitochondrial dysfunction in pathogenesis of amyotrophic lateral sclerosis

doi:10.16352/j.issn.1001-6325.2023.02.332

Abstract

Abstract: Mitochondrial dysfunction plays an important role in the pathogenesis of amyotrophic lateral sclerosis(ALS). The mitochondrial dysfunction will cause severe oxidative stress and disruption in calcium homeostasis. The abnormally released mitochondrial DNA will induce cellular inflammation. These phenomena may explain the loss of motor neurons in ALS patients. As a quality control process, either abnormal increased or decreased mitophagy flux will speed up the pathogenic development of ALS.

Key words: amyotrophic lateral sclerosis, mitochondrial dysfunction

CLC Number:

R741.02

LIU Liyang, LIU Qing, LIU Yaping, ZHANG Xue. Progress in the study of mitochondrial dysfunction in pathogenesis of amyotrophic lateral sclerosis[J]. Basic & Clinical Medicine, 2023, 43(2): 332-335.

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