Advances in immune mechanism of recurrent group A Streptococcus tonsillitis in children

doi:10.16352/j.issn.1001-6325.2023.02.336

Abstract

Abstract: Group A beta-hemolytic Streptococcus (GAS) is a common infectious agent in children which may cause recurrent inflammation of the tonsils, known as recurrent group A Streptococcus tonsillitis (GAS-RT). Recent studies found that GAS-RT is not an infectious disease as traditional sense, but rather than an immunosensitive disease that evades the immune response through the interaction between superantigens (SAgs) and follicular helper T cells (Tfh) in the germinal center (GC), which exerts a cytotoxic effects on B cells in the GC. This theory suggested a potential new strategy for clinical treatement.

Key words: recurrent tonsillitis, immune mechanism, Streptococcus pyrogenic exotoxins A, T follicular helper cells, bacteriotherapy

CLC Number:

SHI Jia, CAI Cheng. Advances in immune mechanism of recurrent group A Streptococcus tonsillitis in children[J]. Basic & Clinical Medicine, 2023, 43(2): 336-340.

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