Abstract: Objective To investigate the effect of urantide on the nonalcoholic fatty liver in atherosclerosis rats. Methods Seventy-two SD rats were randomly divided into control,high-fat diet,positive drug group, urantide 3d group,urantide 7d group and urantide 14d group.The model group was established by injecting a loading dose of vitamin D3 and feeding a high-fat diet.After 3、7 and 14 days of treatment the rats were sacrificed,measuring the TC, TG, LDL, AST, ALT and TBIL in blood serum,detect UⅡ and GPR14 mRNA and protein expression by Western blot and PCR respectively. Results With the increase of treatment dose and incubation time of Urantide, fatty infiltration of the liver was significantly reduced, fat particles significantly decreased; liver function and blood lipids profile significantly improved;UⅡ and GPR14 mRNA and protein expression was significantly decreased．Conclusions The compound of Urantide can ameliorate the symptoms of non-alcoholic fatty liver disease in rats.

Key words: Urantide, atherosclerosis, fatty liver, serology, HE