Abstract: Objective To analyze the high expression of lysine - specific histone demethanase 1（LSD1） in rectal adenocarcinoma and its clinical significance. Method The mRNA expression of LSD1 was detected by q-PCR in rectal adenocarcinoma and its adjacent tissues. The expression of LSD1 protein was detected by western blot and immunohistochemistry, and the correlation between the expression of LSD1 protein and clinicopathological features and prognosis of rectal adenocarcinoma was analyzed. Result The mRNA and protein expression of LSD1 in rectal adenocarcinoma was significantly higher than that in (P < 0.05). High expression of LSD1 was significantly correlated with the degree of tumor differentiation, lymph node metastasis, depth of invasion and TNM staging (P < 0.05). The prognosis of patients with high expression of LSD1 was poor (P < 0.05). Conclusions High expression of LSD1 may promote the occurrence and development of rectal adenocarcinoma, and inhibition of LSD1 may be one of the potential molecular targets for targeted therapy of rectal adenocarcinoma.

Key words: rectal adenocarcinoma, LSD1, prognosis