Abstract: Osteosarcoma (OS) is the most common malignancy in bone tissue. Its high degree of malignancy, prone to children and adolescents. MicroRNA (miRNA) refers to a class of non-coding RNAs having a length of about 18～25 nt. miRNAs play a negative regulatory role at the post-transcriptional level by promoting target mRNA degradation or inhibiting the translation process. miRNAs are associated with the development, invasion, metastasis, and prognosis of osteosarcoma, and play an important role. The differential expression of miRNAs in osteosarcoma cells provides a new target for the early diagnosis and treatment of osteosarcoma.

Key words: osteosarcoma, miRNA, research progress, Gene expression level