Abstract: Objective To study the relationship between rs505802 in SLC22A12, rs6855911, rs737267, rs12498742, rs7442295, rs734553, rs16890979 in SLC2A9 genetic polymorphisms and hypouricemia in Ningxia. Method 6056 subjects were collected by multistage, stratified random cluster sampling method in October and November in 2011 in Ningxia Hui autonomous region, 98 subjects with hypouricemia was selected. According to gender and age, 84 controls were selected. Physical examination and laboratory biochemical index test were conducted for the study population. T test was used to compare general clinical data and biochemical indexs between two groups. SNPs were detected by Sequenom Mass ARRAY technology. By χ2 test, we compared the frequencies of the genotype and allele in each group. Samples representativeness was confirmed through the Hardy-Weinberg inspection. Results The levels of TC, LDLC, and Cr in the patients were lower than those in the control group (all P<0.05). There were significant differences in the distribution of A, G allele frequencies of SLC2A9 gene rs7442295 between two groups. The risk of hypouricemia in patients with A/A genotype was lower than that of A/G genotype (Pc<0.05), indicating that A >G mutation was associated with hypouricemia. Conclusion Polymorphisms of SLC2A9 gene rs7442295 are significant correlation with hyporuricemia in Ningxia.

Key words: Hyporuricemia, Ningxia people, Single nucleotide polymorphisms