Abstract: Genetic studies show that there are multiple of genes involved in pahtogenesis of Alzheimer’s disease. Biochemistry, molecular cell biology and transgenic modeling have already uncovered some of its molecular mechanisms; the development of chemistry, radiology and systems biology is beginning to provide useful biomarkers, and the current situation of pharmaceutical development and clinical trials have been expected to change owning to the emergence of personalized medicine. However, in consideration of multifactoriality of the disease, we should try different ways. In this review, we make a brief discussion of the most common types of dementia.

Key words: Alzheimer’s disease, molecular mechanisms, biomarkers