Abstract: Objective:To report the clinical data and visual outcomes after treatment of patients with dysthyroid optic neuropathy (DON).Methods We retrospectively examined the clinic data of the 38 patients (67 eyes) suffering from DON and analysed the effect of glucocorticoids, radiation and orbital decompression.ResultsThe study included 14 men and 24 women. 32 patients (84.2%) received multiple treatment modalities.LogMAR vision acuity changed from (0.60±0.59) before treatment to (0.18±0.09) after treatment(P<0.01) . There were 59 eyes (88.1%) in the treatment effective group, 8 eyes (11.9%) in the ineffective group.38 eyes underwent initial treatment with intravenous steroid pulse therapy and 35 eyes (92.1%) were effective.29 eyes were treated with other modalities and 24 eyes(82.8%) were effective（P<0.01）. There were 3 eyes (5.1%) suffering from fixed eyeball movement in the effective group, while 4 eyes (50%) in the ineffective group (P<0.05). The thickness of the supraocular muscle group in the effective group was（7.63±1.19）mm, （8.81±0.83）mmin the ineffective group(P<0.05).Mean defect of the visual field was（2.41±2.82） in the effective group and （11.98±7.07） in the ineffective group(P<0.05).Conclusions:Treatment with multiple modalities effectively improved visual outcomes in cases of DON.Intravenous steroid pulse therapy was suggested as the initial modality.

Key words: Thyroid associated ophthalmopathy，Optic neuropathy，Steroid, Decompression, Radiation,