Abstract: Ornithine decarboxylase (ODC) and S-adenosylmethionine decarboxylase (AdoMetDC) are the key enzymes in the pathway of polyamine anabolism, they are closely related to the occurrence and metastasis of tumor. The effects of existing inhibitors are toxic or have poor effect in clinic trails, the inhibitor and other drugs combined together or development of small molecule inhibitors by coupling computational and experimental tools are expected to provide new ideas for tumor treatment.

Key words: polyamines, polyamine anabolism, tumor, ornithine decarboxylase, S-adenosylmethionine decarboxylase