Research progress of CAR-T cells in tumor clinical trials

Basic & Clinical Medicine ›› 2016, Vol. 36 ›› Issue (5): 706-710.

Research progress of CAR-T cells in tumor clinical trials

Received:2015-09-21 Revised:2015-12-03 Online:2016-05-05 Published:2016-04-26
Contact: Xun LI E-mail:lxdr21@126.com

Abstract

Abstract: Currently, chimeric antigen receptor, CAR-related cellular immunotherapy is venerated as the gorgeous star in tumor biotherapy. The CAR-T cell such as which targeted CD19 has obtained the good curative effect in conquering B lymphocyte malignancies. The latest CAT-T related references were collected and summarized to mainly analyse the data of clinical trial, clinical effects and potential adverse reaction treated with CAR-T.

Key words: Chimeric antigen receptor(CAR), T lymphocyte, tumor, clinical trial

[1]	XIA Yujia, YANG Zhenli, LIU Yuqin. Preclinical translational research and application of tumor organoids [J]. Basic & Clinical Medicine, 2024, 44(9): 1214-1218.
[2]	LIU Baoqing, HUANG Rong, LU Yan, LI Kai, ZHANG Ning, LIU Changzheng, SONG Wei. Progress of gastric cancer organoids in basic research and clinical application [J]. Basic & Clinical Medicine, 2024, 44(9): 1219-1222.
[3]	LI Yang, ZHU Lei. Eukaryotic elongation factor 2 kinase is a potential new target for the treatment of tumors [J]. Basic & Clinical Medicine, 2024, 44(7): 1039-1043.
[4]	CHEN Xiaotian, CHEN Chong, LUO Yunping. Impact of MAFB on polarization and function of tumor associated macrophages [J]. Basic & Clinical Medicine, 2024, 44(7): 965-973.
[5]	ZHOU Yue, TONG Anli. Immune microenvironment of pheochromocytomas and paragangliomas [J]. Basic & Clinical Medicine, 2024, 44(6): 742-747.
[6]	ZHANG Liyuan, DU Hanze, PAN Hui. Progress in drug therapy for hypothalamic obesity [J]. Basic & Clinical Medicine, 2024, 44(5): 729-732.
[7]	WANG Tingting, GUO Dan, LU Junyang, XU Lai, DONG Haitao, LIN Dianxin, XIAO Yi. Analysis of cell mutation types of colorectal neuroendocrine tumors [J]. Basic & Clinical Medicine, 2024, 44(4): 523-527.
[8]	LEI Shaoyuan, LI Yulong, SUN Fei, LIU Hongjun, WU Yue, GUO Yansu. The epidemiology and prediction of brain tumors incidence and mortality in China [J]. Basic & Clinical Medicine, 2024, 44(4): 454-458.
[9]	WU Yuhong, YU Caiyuan, YE Shicai. Research progress on the role of NMES1 gene in malignant tumors [J]. Basic & Clinical Medicine, 2024, 44(3): 403-407.
[10]	NAN Lu, GUO Menjie, GAO Yanan, JIA Hongyan. Research progress on the mechanism of annexin A family members in breast cancer [J]. Basic & Clinical Medicine, 2024, 44(3): 393-397.
[11]	CHEN Xue, LUO Tian, WEI Chaojun. Advances in the role of lysophosphatidyl-choline acyltransferase 1 in tumors [J]. Basic & Clinical Medicine, 2024, 44(2): 256-259.
[12]	. Drug therapy for intracranial germ cell tumor [J]. Basic & Clinical Medicine, 2024, 44(10): 1350-1356.
[13]	. Progress of research on the mechanism of GPSM2 in tumor development [J]. Basic & Clinical Medicine, 2024, 44(10): 1447-1450.
[14]	. Long non-coding RNA and diseases [J]. Basic & Clinical Medicine, 2024, 44(10): 1465-1469.
[15]	. CKAP2 and malignant tumors [J]. Basic & Clinical Medicine, 2024, 44(10): 1470-1473.

Research progress of CAR-T cells in tumor clinical trials

PDF

Knowledge

Abstract

Cite this article

share this article

References

Related Articles 15

Recommended Articles

Metrics

Comments