Abstract: The mammalian target of rapamycin(mTOR) is an important signal molecule in a variety of physiological mechanisms, including protein synthesis, cell proliferation, cell cycle, energy metabolism, autophagy, etc. It is increasingly apparent that mTOR deregulation occurs in cancer and metabolism disorders. The transcription factors of downstream of mTOR such as HIF1α, c-Myc, FoxO1, SREBPs, PPARγ/PPARα and TFEB play key roles in regulating the metabolism of glucose and lipid.

Key words: mTOR, glucose metabolism, lipid metabolism, transcription factor