Basic & Clinical Medicine ›› 2024, Vol. 44 ›› Issue (1): 119-123.doi: 10.16352/j.issn.1001-6325.2024.01.0119

• Mini Reviews • Previous Articles     Next Articles

Progress of the effect of hydroxyacyl- coenzyme A dehydrogenase in cancer development and its mechanism

WU Guojia1, ZHAI Shujie1, SUN Xiao1, HUANG Yiran1, LI Yongmei1, SUN Li2*   

  1. 1. Department of Medical Microbiology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300211;
    2. Department of Gynaecology and Obstetrics, the Second Hospital of Tianjin Medical University, Tianjin 300070, China
  • Received:2023-08-17 Revised:2023-11-03 Online:2024-01-05 Published:2023-12-25
  • Contact: *:sunl2013@sina.com

Abstract: A close relationship between fatty acid metabolism and cancer development is well-established. The hydroxyacyl-coenzyme a dehydrogenase (HADH), a key enzyme in fatty acid beta-oxidation, has recently been identified as an anti-oncogenic factor in various cancers and an oncogenic factor in conditions like acute myeloid leukemia. In cancer cells, HADH not only directly catalyzes fatty acid beta-oxidation but also indirectly influences multiple signaling pathways such as PPAR, TNF-α, JAK-STAT3, PI3K/Akt, IFN-γ, MAPK, and non-canonical Wnt signaling pathways, affecting cancer cell proliferation and migration. HADH shows promise as a potential tumor biomarker for diagnosis, treatment, and prognosis in different cancer types, holding significant clinical value.

Key words: hydroxyacyl-coenzyme A dehydrogenase, lipid metabolism, fatty acid β-oxidation, tumor suppressor gene, tumor marker

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