Abstract: The Hippo-yap pathway is a newly growth regulatory pathway and regulate both cell growth and apoptosis, aberrant signaling pathway contribute to tumorigenesis. YAP protein is also involved in the mediate AKT-mTORC, WNT and MAPK signaling pathways, thereby affecting tumor cell growth, invasion and metastasis. YAP protein expression is increased in many types of human tumors, perhaps to become new therapeutic targets of tumor.

Key words: yap protein, singnal pathway, cancer