Abstract: Dedifferentiation is an important life phenomenon in cell biology, which can be observed both in vivo and in vitro. The cells resulting from the dedifferentiation have the characteristics of undifferentiated cells. The process of dedifferentiation involving cell autophagy, recirculation of cells structure and a series of biological behavior is complex. More and more studies demonstrate the close relation between cell dedifferentiation and cell renewal, tissue regeneration and tumorigenesis, etc.

Key words: dedifferentiation, cell therapy, prospect