Efficacy of continuous renal replacement therapy combined with hemoperfusion in sepsis patients with acute kidney injury

doi:10.16352/j.issn.1001-6325.2026.02.0267

Abstract

Abstract: Objective To investigate the efficacy of continuous renal replacement therapy combined with hemoperfusion in treating sepsis patients with acute kidney injury and its effect on inflammatory markers PCT, CRP and HMGB1. Methods From March 2023 to March 2024,60 patients with sepsis-induced acute kidney injury admitted to Yinchuan First People's Hospital were selected. According to the random number table method, they were divided into a control group receiving CRRT treatment and an observation group receiving CRRT combined with HP treatment, with 30 cases in each group. The sequential organ failure assessment score, levels of serum creatinine (Scr), urea nitrogen (BUN), PCT, CRP, HMGB1, acute physiology and chronic health evaluation Ⅱ score were observed in the two groups, and the 28-day mortality rate was recorded. Results Compared with the control group: after treatment, the renal function indexes Scr, BUN levels and APACHE Ⅱ scores of the observation group were significantly decreased (P＜0.05); The levels of inflammatory factors PCT, HMGB1 and IL-6 in the observation group were significantly decreased (P＜0.05). The hospitalization time of the observation group was (14.4±3.4) vs (22.5±5.3)d, the mechanical ventilation time was (9.4±2.2) vs (14.6±3.1)d, and the 28-day mortality rate in observation group was lower (3.33% vs 20.00%, P＜0.05). The overall efficacy of the observation group was better (93.33% vs 73.33%, P＜0.05). Conclusions CRRT combined with HP in treating sepsis with acute kidney injury can reduce the inflammatory response, promote the recovery of renal function, reduce the 28-day mortality rate, and improve the overall efficacy.

Key words: continuous renal replacement therapy, hemoperfusion, sepsis, acute kidney injury, procalcitonin

CLC Number:

R459.7

TAO Ningning, WANG Haichao, SU Yueqin. Efficacy of continuous renal replacement therapy combined with hemoperfusion in sepsis patients with acute kidney injury[J]. Basic & Clinical Medicine, 2026, 46(2): 267-272.

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