Abstract: Sepsis is one of the most common critical conditions in clinical practice, with a persistently high mortality rate. As the core pathological mechanism of sepsis, cytokine storm, the continuous activation of the immune system and the disordered release of a large number of cytokines cause severe damage to the patient's tissues and organs, leading to systemic inflammatory response syndrome and even multiple organ dysfunction syndrome, posing a significant threat to patient health. Therefore, this article reviews the role of cytokine storm in sepsis and current therapeutic strategies.

Key words: sepsis, cytokine storm, innate immunity, systemic inflammatory response syndrome, multiple organ dysfunction syndrome